ICM0201, a New Inhibitor of Osteoclastogenesis from Cunninghamella sp. F-1490: I. Taxonomy, Fermentation, Isolation and Biological Activities

In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78μg/ml and showed weak cytoto...

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Bibliographic Details
Published in:Journal of antibiotics 2003/03/25, Vol.56(3), pp.209-213
Main Authors: INOUE, HIROYUKI, KUMAGAI, HIROYUKI, OSONO, MICHIYO, MATSUFUJI, MOTOKO, SAMESHIMA, TOMOHIRO, KAWAMURA, NAOTO, SOMENO, TETSUYA, ISHIZUKA, MASAAKI, TAKEUCHI, TOMIO
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Cunninghamella
Cunninghamella - chemistry
Fermentation
Heterocyclic Compounds, 3-Ring - classification
Heterocyclic Compounds, 3-Ring - isolation & purification
Heterocyclic Compounds, 3-Ring - metabolism
Heterocyclic Compounds, 3-Ring - pharmacology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Oxazines - classification
Oxazines - isolation & purification
Oxazines - metabolism
Oxazines - pharmacology
Tumor Cells, Cultured
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Summary:In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78μg/ml and showed weak cytotoxicity against bone marrow cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.56.209