Assembly of Cytochrome c Oxidase within the Mitochondrion

Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of f...

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Bibliographic Details
Published in:Accounts of chemical research 2003-05, Vol.36 (5), p.309-316
Main Authors: Carr, Heather S, Winge, Dennis R
Format: Article
Language:English
Subjects:
Electron Transport Complex IV - metabolism
Mitochondria - enzymology
Models, Molecular
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Summary:Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar0200807