Assembly of Cytochrome c Oxidase within the Mitochondrion

Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of f...

Full description

Saved in:
Bibliographic Details
Published in:Accounts of chemical research 2003-05, Vol.36 (5), p.309-316
Main Authors: Carr, Heather S, Winge, Dennis R
Format: Article
Language:English
Subjects:
Electron Transport Complex IV - metabolism
Mitochondria - enzymology
Models, Molecular
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73
cites cdi_FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73
container_end_page 316
container_issue 5
container_start_page 309
container_title Accounts of chemical research
container_volume 36
creator Carr, Heather S
Winge, Dennis R
description Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.
doi_str_mv 10.1021/ar0200807
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73318718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73318718</sourcerecordid><originalsourceid>FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73</originalsourceid><addsrcrecordid>eNptkEFLwzAYhoMobk4P_gHpRcFDNUnTJD3OoVOYbODUY0jSlGWuzUxa3P69HR3z4un7Pt6H94MHgEsE7xDE6F56iCHkkB2BPkoxjAnP-DHoQwhRuxPcA2chLNsTE8pOQQ9hlqaUwD7IhiGYUq22kSui0bZ2euFdaSIdTTc2l8FEP7Ze2CqqFyZ6tbvcVbm3rjoHJ4VcBXOxnwPw_vQ4Hz3Hk-n4ZTScxJKgtI5zqgussSpyhShkBhnKJSJKKUILkxoKTcaKPNO5SrKUSYh5qghnBSaYZZolA3DT9a69-25MqEVpgzarlayMa4JgSYI4Q7wFbztQexeCN4VYe1tKvxUIip0ncfDUslf70kaVJv8j92JaIO4AG2qzOeTSfwnKEpaK-exNPGTjDzQjn4K2_HXHSx3E0jW-ap388_gX6hd8xg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73318718</pqid></control><display><type>article</type><title>Assembly of Cytochrome c Oxidase within the Mitochondrion</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read &amp; Publish Agreement 2022-2024 (Reading list)</source><creator>Carr, Heather S ; Winge, Dennis R</creator><creatorcontrib>Carr, Heather S ; Winge, Dennis R</creatorcontrib><description>Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.</description><identifier>ISSN: 0001-4842</identifier><identifier>EISSN: 1520-4898</identifier><identifier>DOI: 10.1021/ar0200807</identifier><identifier>PMID: 12755640</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Electron Transport Complex IV - metabolism ; Mitochondria - enzymology ; Models, Molecular</subject><ispartof>Accounts of chemical research, 2003-05, Vol.36 (5), p.309-316</ispartof><rights>Copyright © 2003 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73</citedby><cites>FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12755640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carr, Heather S</creatorcontrib><creatorcontrib>Winge, Dennis R</creatorcontrib><title>Assembly of Cytochrome c Oxidase within the Mitochondrion</title><title>Accounts of chemical research</title><addtitle>Acc. Chem. Res</addtitle><description>Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.</description><subject>Electron Transport Complex IV - metabolism</subject><subject>Mitochondria - enzymology</subject><subject>Models, Molecular</subject><issn>0001-4842</issn><issn>1520-4898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNptkEFLwzAYhoMobk4P_gHpRcFDNUnTJD3OoVOYbODUY0jSlGWuzUxa3P69HR3z4un7Pt6H94MHgEsE7xDE6F56iCHkkB2BPkoxjAnP-DHoQwhRuxPcA2chLNsTE8pOQQ9hlqaUwD7IhiGYUq22kSui0bZ2euFdaSIdTTc2l8FEP7Ze2CqqFyZ6tbvcVbm3rjoHJ4VcBXOxnwPw_vQ4Hz3Hk-n4ZTScxJKgtI5zqgussSpyhShkBhnKJSJKKUILkxoKTcaKPNO5SrKUSYh5qghnBSaYZZolA3DT9a69-25MqEVpgzarlayMa4JgSYI4Q7wFbztQexeCN4VYe1tKvxUIip0ncfDUslf70kaVJv8j92JaIO4AG2qzOeTSfwnKEpaK-exNPGTjDzQjn4K2_HXHSx3E0jW-ap388_gX6hd8xg</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Carr, Heather S</creator><creator>Winge, Dennis R</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Assembly of Cytochrome c Oxidase within the Mitochondrion</title><author>Carr, Heather S ; Winge, Dennis R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Electron Transport Complex IV - metabolism</topic><topic>Mitochondria - enzymology</topic><topic>Models, Molecular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carr, Heather S</creatorcontrib><creatorcontrib>Winge, Dennis R</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Accounts of chemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carr, Heather S</au><au>Winge, Dennis R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assembly of Cytochrome c Oxidase within the Mitochondrion</atitle><jtitle>Accounts of chemical research</jtitle><addtitle>Acc. Chem. Res</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>36</volume><issue>5</issue><spage>309</spage><epage>316</epage><pages>309-316</pages><issn>0001-4842</issn><eissn>1520-4898</eissn><abstract>Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>12755640</pmid><doi>10.1021/ar0200807</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0001-4842
ispartof Accounts of chemical research, 2003-05, Vol.36 (5), p.309-316
issn 0001-4842
1520-4898
language eng
recordid cdi_proquest_miscellaneous_73318718
source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Electron Transport Complex IV - metabolism
Mitochondria - enzymology
Models, Molecular
title Assembly of Cytochrome c Oxidase within the Mitochondrion
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A34%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assembly%20of%20Cytochrome%20c%20Oxidase%20within%20the%20Mitochondrion&rft.jtitle=Accounts%20of%20chemical%20research&rft.au=Carr,%20Heather%20S&rft.date=2003-05-01&rft.volume=36&rft.issue=5&rft.spage=309&rft.epage=316&rft.pages=309-316&rft.issn=0001-4842&rft.eissn=1520-4898&rft_id=info:doi/10.1021/ar0200807&rft_dat=%3Cproquest_cross%3E73318718%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a415t-d6cf2c2bfdb1607e1e68a14bbb46fe5e60e97fd9cdb3957a0285b487f24279c73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73318718&rft_id=info:pmid/12755640&rfr_iscdi=true