Efficacy and tolerance of a new gentamicin collagen fleece (Septocoll®) after surgical treatment of a pilonidal sinus

Objective  Pilonidal sinus is common. It causes substantial loss of working hours. The major disadvantage of open wound treatment is the long time required for healing. Primary wound closure is on the other hand often followed by infection. A controlled, multicentre trial was carried out to evaluate...

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Bibliographic Details
Published in:Colorectal disease 2003-05, Vol.5 (3), p.222-227
Main Authors: Holzer, B., Grüßner, U., Brückner, B., Houf, M., Kiffner, E., Schildberg, F. W., Vogel, P., Rosen, H. R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Collagen - therapeutic use
Female
Follow-Up Studies
gentamicin
Gentamicins - therapeutic use
Humans
Male
Middle Aged
Pilonidal sinus
Pilonidal Sinus - surgery
Postoperative Complications
primary closure
Prospective Studies
Surgical Wound Infection - etiology
Surgical Wound Infection - prevention & control
Time Factors
Wound Healing - drug effects
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Summary:Objective  Pilonidal sinus is common. It causes substantial loss of working hours. The major disadvantage of open wound treatment is the long time required for healing. Primary wound closure is on the other hand often followed by infection. A controlled, multicentre trial was carried out to evaluate the efficacy of a new gentamicin collagen fleece (Septocoll®) combined with primary closure. Patients and methods  One hundred and three patients (88 men, 15 women, median age 30 years) were included. Fifty‐one were randomised to gentamicin fleece plus primary closure (Genta Group), and 52 patients to open treatment alone (Open Group). Results  The median interval to wound healing was 17 days in the Genta group and 68 days in the Open group (P = 0.0001, log‐rank test). Two patients in Group 1 developed infection within the first two weeks, requiring reopening of the wound, with primary wound healing occurring in 73%. Failure of primary healing (27%) was usually due to seroma or spontaneous dehiscence which subsequently healed. Conclusion  The combination of gentamicin collagen fleece (Septocoll®) with primary closure resulted in a shorter period to healing than the open technique without unwanted effects.
ISSN:1462-8910
1463-1318
DOI:10.1046/j.1463-1318.2003.00471.x