26-Hydroxyecdysone: New Insect Molting Hormone from the Egg of the Tobacco Hornworm

Five kilograms of tobacco hornworn eggs (48 to 64 hours old) afforded 26.5 milligrams of a new crystalline insect molting hormone identified as 26-hydroxyecdysone. The three known insect ecdysones--α-ecdysone, 20-hydroxyecdysone, and 20,26-dihydroxyecdysone-were also present but in much smaller quan...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-04, Vol.180 (4083), p.307-308
Main Authors: Kaplanis, J. N., Robbins, W. E., Thompson, M. J., Dutky, S. R.
Format: Article
Language:English
Subjects:
Hormones
Hydroxyls
Insect development
Insect eggs
Insect hormones
Insect identification
Insect pathology
Molecules
Molting
Steroids
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Summary:Five kilograms of tobacco hornworn eggs (48 to 64 hours old) afforded 26.5 milligrams of a new crystalline insect molting hormone identified as 26-hydroxyecdysone. The three known insect ecdysones--α-ecdysone, 20-hydroxyecdysone, and 20,26-dihydroxyecdysone-were also present but in much smaller quantities. The new hormone is the predominant molting hormone in the hornworm during this stage of embryonic development. These results taken in context with the current knowledge of the chemistry and biochemistry of the molting hormones during postembryonic development in the hornworm indicate quantitative and qualitative differences in the biosynthetic-metabolic pathways as well as in the ecdysones in different developmental stages of this insect.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.180.4083.307