Age-related phenomena in the lumbar intervertebral discs : lipofuscin and amyloid deposition

In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofus...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1992-10, Vol.17 (10), p.1194-1198
Main Authors: YASUMA, T, ARAI, K, SUZUKI, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging - metabolism
Amyloid - analysis
Biological and medical sciences
Child
Diseases of the osteoarticular system
Diseases of the spine
Humans
Intervertebral Disc - metabolism
Intervertebral Disc Displacement - metabolism
Lipofuscin - analysis
Lumbar Vertebrae - metabolism
Medical sciences
Middle Aged
Staining and Labeling
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Summary:In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofuscin was seen in the discs of individuals older than 20 years of age and amyloids in the discs of individuals older than 15 years of age. It is speculated that amyloids and lipofuscin are a sign of aging in the intervertebral disc as in other tissues. Furthermore, amyloids and lipofuscin were seen in the operated discs of young individuals than in the autopsy cases.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-199210000-00011