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Age-related phenomena in the lumbar intervertebral discs : lipofuscin and amyloid deposition

In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofus...

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Published in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 1992-10, Vol.17 (10), p.1194-1198
Main Authors:	YASUMA, T, ARAI, K, SUZUKI, F
Format:	Article
Language:	English
Subjects:	Adolescent Adult Aged Aged, 80 and over Aging - metabolism Amyloid - analysis Biological and medical sciences Child Diseases of the osteoarticular system Diseases of the spine Humans Intervertebral Disc - metabolism Intervertebral Disc Displacement - metabolism Lipofuscin - analysis Lumbar Vertebrae - metabolism Medical sciences Middle Aged Staining and Labeling
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container_title	Spine (Philadelphia, Pa. 1976)
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creator	YASUMA, T ARAI, K SUZUKI, F
description	In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofuscin was seen in the discs of individuals older than 20 years of age and amyloids in the discs of individuals older than 15 years of age. It is speculated that amyloids and lipofuscin are a sign of aging in the intervertebral disc as in other tissues. Furthermore, amyloids and lipofuscin were seen in the operated discs of young individuals than in the autopsy cases.
doi_str_mv	10.1097/00007632-199210000-00011
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In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofuscin was seen in the discs of individuals older than 20 years of age and amyloids in the discs of individuals older than 15 years of age. It is speculated that amyloids and lipofuscin are a sign of aging in the intervertebral disc as in other tissues. 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subjects	Adolescent Adult Aged Aged, 80 and over Aging - metabolism Amyloid - analysis Biological and medical sciences Child Diseases of the osteoarticular system Diseases of the spine Humans Intervertebral Disc - metabolism Intervertebral Disc Displacement - metabolism Lipofuscin - analysis Lumbar Vertebrae - metabolism Medical sciences Middle Aged Staining and Labeling
title	Age-related phenomena in the lumbar intervertebral discs : lipofuscin and amyloid deposition
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