Allergic Encephalomyelitis: Passive Transfer Prevented by Encephalitogen

Allergic encephalomyelitis was produced in rats by passive transfer of lymph node cells from donors immunized intradermally with neural tissue or an encephalitogenic basic protein plus adjuvants. The same basic protein, injected intravenously into the recipients before or after transfer of lymph nod...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-09, Vol.161 (3846), p.1155-1157
Main Authors: Levine, Seymour, Hoenig, Eugene M., Kies, Marian W.
Format: Article
Language:English
Subjects:
Allergies
Antigens
Autoimmune diseases
Experimental autoimmune encephalomyelitis
Lesions
Lymph nodes
Lymphocytes
Phagocytes
Spinal cord
Tissue donation
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Summary:Allergic encephalomyelitis was produced in rats by passive transfer of lymph node cells from donors immunized intradermally with neural tissue or an encephalitogenic basic protein plus adjuvants. The same basic protein, injected intravenously into the recipients before or after transfer of lymph node cells, prevented the disease. Even established lesions were reversed. Inhibition by basic protein was specific for encephalomyelitis; it had no effect on passive transfer of allergic adrenalitis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.161.3846.1155