Angiotensin Dependence of Endothelium-Mediated Renal Hemodynamics

Endothelium-derived relaxing factor has been shown to regulate renal blood flow, and inhibition of its synthesis increases blood pressure and renal vascular resistance and decreases renal blood flow. Using the substrate antagonist N-nitro-L-arginine methyl ester (L-NAME), we tested whether renal vas...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-11, Vol.20 (5), p.643-650
Main Authors: Sigmon, David H, Carretero, Oscar A, Beierwaltes, William H
Format: Article
Language:English
Subjects:
Angiotensin II - physiology
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Biological and medical sciences
Biphenyl Compounds - pharmacology
Blood Pressure - drug effects
Blood vessels and receptors
Enalaprilat - pharmacology
Endothelium, Vascular - physiology
Fundamental and applied biological sciences. Psychology
Hemodynamics - drug effects
Imidazoles - pharmacology
Kinins - antagonists & inhibitors
Losartan
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide - antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Renal Circulation - drug effects
Tetrazoles - pharmacology
Vertebrates: cardiovascular system
Citations: Items that cite this one
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Summary:Endothelium-derived relaxing factor has been shown to regulate renal blood flow, and inhibition of its synthesis increases blood pressure and renal vascular resistance and decreases renal blood flow. Using the substrate antagonist N-nitro-L-arginine methyl ester (L-NAME), we tested whether renal vasoconstriction induced by endothelium-derived relaxing factor synthesis inhibition could be mediated in part by angiotensin II. In 14 control rats, 10 mg/kg body wt L-NAME increased blood pressure from 106±6 to 126±6 mm Hg (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.20.5.643