NADPH oxidase signaling and cardiac myocyte function

Abstract The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovas...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2009-07, Vol.47 (1), p.15-22
Main Authors: Akki, Ashwin, Zhang, Min, Murdoch, Colin, Brewer, Alison, Shah, Ajay M
Format: Article
Language:English
Subjects:
Animals
Calcium Signaling - physiology
Cardiac myocytes
Cardiomegaly - metabolism
Cardiovascular
Contraction
Humans
Hypertrophy
Isoenzymes - metabolism
Isoenzymes - physiology
Models, Biological
Myocytes, Cardiac - metabolism
NADPH oxidase
NADPH Oxidases - metabolism
NADPH Oxidases - physiology
Redox
Remodeling
Signal Transduction - physiology
Signaling
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Summary:Abstract The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2009.04.004