Particle aggregation monitoring by speckle size measurement; application to blood platelets aggregation

We report on a new method based on speckle size analysis and devoted to particle aggregation measurements. The experimental measurements give the speckle size variation during a salt aggregation process of polystyrene microspheres. The measurements are taken at a fixed monomer concentration, varying...

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Bibliographic Details
Published in:Optics express 2004-09, Vol.12 (19), p.4596-4601
Main Authors: Piederrière, Yann, Le Meur, J, Cariou, J, Abgrall, J, Blouch, M
Format: Article
Language:English
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Summary:We report on a new method based on speckle size analysis and devoted to particle aggregation measurements. The experimental measurements give the speckle size variation during a salt aggregation process of polystyrene microspheres. The measurements are taken at a fixed monomer concentration, varying the salt concentration. Moreover, we applied this technique to follow blood platelet aggregation, usually monitored with a visible light transmittance photometer (aggregometer). Aggregation process was induced by ADP (adenosine diphosphate) addition, then we measured the speckle size variation versus time at two different ADP concentrations.
ISSN:1094-4087
1094-4087
DOI:10.1364/opex.12.004596