Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade

Aim:  Beta‐blockers reduce exercise capacity by attenuated increase in cardiac output, but it remains unknown whether performance also relates to attenuated cerebral oxygenation. Methods:  Acting as their own controls, eight healthy subjects performed a continuous incremental cycle test to exhaustio...

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Bibliographic Details
Published in:Acta Physiologica 2009-07, Vol.196 (3), p.295-302
Main Authors: Seifert, T., Rasmussen, P., Secher, N. H., Nielsen, H. B.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Adult
Biological and medical sciences
Blood Pressure - drug effects
Blood Pressure - physiology
Brain - blood supply
Brain - drug effects
Brain - metabolism
brain oxygenation
Carbon Dioxide - blood
cardiac output
Cardiac Output - drug effects
Cardiac Output - physiology
cerebral mitochondrial oxygen tension
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Exercise - physiology
Exercise Test
Exercise Tolerance - drug effects
Exercise Tolerance - physiology
Frontal Lobe - blood supply
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Fundamental and applied biological sciences. Psychology
Heart Rate - drug effects
Heart Rate - physiology
Humans
Male
Mitochondria - metabolism
Oxygen - blood
Oxygen - metabolism
Partial Pressure
Propranolol - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
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Summary:Aim:  Beta‐blockers reduce exercise capacity by attenuated increase in cardiac output, but it remains unknown whether performance also relates to attenuated cerebral oxygenation. Methods:  Acting as their own controls, eight healthy subjects performed a continuous incremental cycle test to exhaustion with or without administration of the non‐selective beta‐blocker propranolol. Changes in cerebral blood flow velocity were measured with transcranial Doppler ultrasound and those in cerebral oxygenation were evaluated using near‐infrared spectroscopy and the calculated cerebral mitochondrial oxygen tension derived from arterial to internal jugular venous concentration differences. Results:  Arterial lactate and cardiac output increased to 15.3 ± 4.2 mm and 20.8 ± 1.5 L min−1 respectively (mean ± SD). Frontal lobe oxygenation remained unaffected but the calculated cerebral mitochondrial oxygen tension decreased by 29 ± 7 mmHg (P 
ISSN:1748-1708
1748-1716
DOI:10.1111/j.1748-1716.2008.01946.x