FlexServ: an integrated tool for the analysis of protein flexibility

• Published in: Bioinformatics 2009-07, Vol.25 (13), p.1709-1710
• Main Authors: Camps, Jordi, Carrillo, Oliver, Emperador, Agustí, Orellana, Laura, Hospital, Adam, Rueda, Manuel, Cicin-Sain, Damjan, D'Abramo, Marco, Gelpí, Josep Lluís, Orozco, Modesto
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Computational Biology - methods; Databases, Protein; Fundamental and applied biological sciences. Psychology; General aspects; Internet; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Protein Conformation; Proteins - chemistry; Sequence Analysis, Protein; Software
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btp304

FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics. Availability: http://mmb.pcb.ub.es/FlexServ; http://www.inab.org Contact: [e-mail] or [e-mail] Supplementary information: Additional information and methodology details can be found at http://mmb.pcb.ub.es/FlexServ/help.