Thoracic paravertebral ganglioneuroma with high immunohistochemical expression of TrkA

A 21‐year‐old man, who had previously undergone a total resection for a retroperitoneal ganglioneuroblastoma at 7 months of age, was revealed to have a thoracic paravertebral ganglioneuroma, in which immunohistochemical expression of neuron‐specific enolase and neurofilament was noted. Furthermore,...

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Bibliographic Details
Published in:Neuropathology 1999-01, Vol.19 (1), p.51-56
Main Authors: Nishio, Shunji, Hamada, Yasuhiro, Nakagawara, Akira, Haga, Sei, Fukui, Satoshi Suzuki1 and Masashi
Format: Article
Language:English
Subjects:
ganglioneuroblastoma
ganglioneuroma
sym-pathetic ganglia
TrkA
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Summary:A 21‐year‐old man, who had previously undergone a total resection for a retroperitoneal ganglioneuroblastoma at 7 months of age, was revealed to have a thoracic paravertebral ganglioneuroma, in which immunohistochemical expression of neuron‐specific enolase and neurofilament was noted. Furthermore, immunohistochemical expression of TrkA, which is a high‐affinity receptor for nerve growth factor, was evident. Although the exact histogenesis remains uncertain, TrkA was considered to be involved in the development of this thoracic paravertebral tumor.
ISSN:0919-6544
1440-1789
DOI:10.1046/j.1440-1789.1999.00210.x