Visualization and quantification of renal R2 changes during water diuresis

Purpose To refine and evaluate methods for analysis of renal blood oxygenation level dependent (BOLD) MRI data. Materials and Methods Color R2* maps and regions‐of‐interest (ROIs) on the borderline between cortex and medulla were applied to renal BOLD MRI data of a group of 13 young female subjects....

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2003-06, Vol.17 (6), p.676-682
Main Authors: Zuo, Chun S., Rofsky, Neil M., Mahallati, Houman, Yu, Jeongsik, Zhang, Ming, Gilbert, Scott, Epstein, Franklin H.
Format: Article
Language:English
Subjects:
Adult
Body Water - metabolism
BOLD MRI
cortico-medullary borderline
Diuresis - physiology
Female
Humans
Kidney - anatomy & histology
Magnetic Resonance Imaging
R2 map
Reference Values
ROI
tenal oxygenation
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Summary:Purpose To refine and evaluate methods for analysis of renal blood oxygenation level dependent (BOLD) MRI data. Materials and Methods Color R2* maps and regions‐of‐interest (ROIs) on the borderline between cortex and medulla were applied to renal BOLD MRI data of a group of 13 young female subjects. Results The distribution of R2* within the kidneys was heterogeneous and the response of human kidneys to water diuresis was patchy. R2* values at the cortico‐medullary border region have a smaller variation than in wider cortical or medullary regions and are sensitive to physiological changes produced by water diuresis. Conclusion These methods provide improved visualization of the regional distribution of R2* and its variations and more precise quantification of the changes in renal R2* produced by water diuresis. J. Magn. Reson. Imaging 2003;17:676–682. © 2003 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.10314