Dinoprostone vaginal insert versus intravenous oxytocin to reduce postpartum blood loss following vaginal or cesarean delivery

To compare the impact of a dinoprostone vaginal insert and intravenous oxytocin in reducing blood loss of women undergoing vaginal or cesarean delivery. This study was conducted among term singleton pregnancies delivered vaginally or by elective cesarean section. In the vaginally delivered cases, ac...

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Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology 2010, Vol.37 (1), p.53-55
Main Authors: Ozalp, E, Tanir, H M, Sener, T
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Adult
Delayed-Action Preparations
Delivery, Obstetric
Diarrhea - epidemiology
Dinoprostone - therapeutic use
Female
Fever - epidemiology
Humans
Infusions, Intravenous
Nausea - epidemiology
Oxytocics - therapeutic use
Oxytocin - therapeutic use
Postpartum Hemorrhage - prevention & control
Pregnancy
Prospective Studies
Shivering
Vomiting - epidemiology
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Summary:To compare the impact of a dinoprostone vaginal insert and intravenous oxytocin in reducing blood loss of women undergoing vaginal or cesarean delivery. This study was conducted among term singleton pregnancies delivered vaginally or by elective cesarean section. In the vaginally delivered cases, active management of the third stage of labor was conducted. During cesarean delivery, 20 IU of intravenous oxytocin was administered. Women, who either delivered via the vaginal or abdominal route, were then randomly allocated to receive 10 mg vaginal dinoprostone insert for 12 hours (group I, n: 100) or intravenous oxytocin (group II, n: 100), respectively. Mean blood loss and need for additional uterotonics and postpartum hemoglobin and hematocrit levels at 24 and 36 hours after delivery did not differ between the two groups. Women allocated to the dinoprostone vaginal insert arm experienced more nausea and vomiting. Dinoprostone vaginal insert was as effective as intravenous oxytocin in the prevention of postpartum blood loss.
ISSN:0390-6663