Cigarette smoking and proteinuria in Taiwanese men with Type 2 diabetes mellitus

Diabet. Med. 27, 295–302 (2010) Aims  Cigarette smoking is a well‐known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose–response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods  Five hundred and nine m...

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Published in:Diabetic medicine 2010-03, Vol.27 (3), p.295-302
Main Authors: Hsu, C. C., Hwang, S. J., Tai, T. Y., Chen, T., Huang, M. C., Shin, S. J., Wen, C. P., Shih, Y. T., Yang, H. J., Chang, C. T., Chang, C. J., Loh, C. H., Fuh, M. T., Li, Y. S., Chang, H.-Y.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cigarette smoking
Cohort Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Dose-Response Relationship, Drug
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glycated Hemoglobin A - analysis
Humans
Logistic Models
Male
Medical sciences
Middle Aged
proteinuria
Proteinuria - etiology
Risk Factors
Smoking - adverse effects
Taiwan
Type 2 diabetes mellitus
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Diabet. Med. 27, 295–302 (2010) Aims  Cigarette smoking is a well‐known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose–response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods  Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack‐years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin‐to‐creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results  Compared with non‐smokers, those who had smoked 15–30 or more than 30 pack‐years were respectively 2.78 (95% CI 1.34–5.76, P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2010.02947.x