Production and Treatment of Granulocytopenia and Anemia in Rats Fed Sulfonamides in Purified Diets

(1) A severe granulocytopenia or anemia, or both, have been produced in rats fed sulfathiazole, sulfadiazine or sulfanilamide at a 1 per cent. level in purified diets. (2) Treatment with certain liver fractions orally has succeeded in correcting the granulocytopenia in four days and the anemia in ab...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1943-07, Vol.98 (2531), p.20-22
Main Authors: Kornberg, Arthur, Daft, Floyd S., Sebrell, W. H.
Format: Article
Language:English
Subjects:
Agranulocytosis
Anemia
Blood
Blood plasma
Diet
Hemoglobins
Heparin
Liver
Photoelectric cells
Special Articles
Sulfonamides
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Summary:(1) A severe granulocytopenia or anemia, or both, have been produced in rats fed sulfathiazole, sulfadiazine or sulfanilamide at a 1 per cent. level in purified diets. (2) Treatment with certain liver fractions orally has succeeded in correcting the granulocytopenia in four days and the anemia in about 10 days in spite of continued ingestion by these animals of the sulfonamide-containing diet.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.98.2531.20