A new prognostic model for hepatocellular carcinoma based on total tumor volume: The Taipei Integrated Scoring system

Background & Aims The currently used staging systems for hepatocellular carcinoma (HCC) are not satisfactory. The optimal prognostic model for HCC is still under intense debate. This study aimed to propose a new staging system for HCC based on total tumor volume (TTV) and to compare it with the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 2010-07, Vol.53 (1), p.108-117
Main Authors: Hsu, Chia-Yang, Huang, Yi-Hsiang, Hsia, Cheng-Yuan, Su, Chien-Wei, Lin, Han-Chieh, Loong, Che-Chuan, Chiou, Yi-You, Chiang, Jen-Huey, Lee, Pui-Ching, Huo, Teh-Ia, Lee, Shou-Dong
Format: Article
Language:English
Subjects:
Aged
alpha-Fetoproteins - metabolism
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - classification
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Child–Turcotte–Pugh
Cirrhosis
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms - blood
Liver Neoplasms - classification
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Model for end-stage liver disease (MELD)
Models, Biological
Neoplasm Staging - methods
Other diseases. Semiology
Predictive Value of Tests
Prognosis
Retrospective Studies
Sodium
Sodium - blood
Taiwan
Total tumor volume
Tumor Burden
Tumors
α-Fetoprotein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background & Aims The currently used staging systems for hepatocellular carcinoma (HCC) are not satisfactory. The optimal prognostic model for HCC is still under intense debate. This study aimed to propose a new staging system for HCC based on total tumor volume (TTV) and to compare it with the currently used systems. Methods A total of 2030 HCC patients undergoing different treatment strategies were retrospectively analyzed. TTV was defined as the sum of the volume of each tumor [(4/3) × 3.14 × (radius of tumor in cm)3 ]. The discriminatory ability of the TTV-based staging system and the four current systems, including the Barcelona Clinic Liver Cancer, Cancer of the Liver Italian Program (CLIP), Japan Integrated Staging system, and Tokyo system, was examined by comparing the Akaike information criterion (AIC) using the Cox proportional hazards model. Results A higher TTV correlated well with the decreased survival in HCC patients ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2010.01.038