Relationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythm

To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV). The numbers of circulating CD34+/KDR+ EPCs were determined with flow cytometry in 51 conse...

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Published in:Europace (London, England) England), 2010-04, Vol.12 (4), p.517-521
Main Authors: Siu, Chung-Wah, Watson, Timothy, Lai, Wing-Hon, Lee, Yee-Ki, Chan, Yap-Hang, Ng, Kwong-Man, Lau, Chu-Pak, Lip, Gregory Y H, Tse, Hung-Fat
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - pathology
Atrial Fibrillation - therapy
Biomarkers
Coronary Artery Disease - pathology
Electric Countershock
Endothelial Cells - cytology
Female
Flow Cytometry
Hematopoietic Stem Cells - cytology
Humans
Male
Predictive Value of Tests
Recurrence
Sinoatrial Node - physiology
Stroke - pathology
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Summary:To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV). The numbers of circulating CD34+/KDR+ EPCs were determined with flow cytometry in 51 consecutive patients with persistent AF [the mean age: 67 +/- 1.3 years, male (65%)] prior to DCCV and were compared with that of age- and sex-matched controls, and cohorts of patients with coronary artery disease and ischaemic stroke. The AF recurrence rate at 1 year was also determined. The EPCs in patients with persistent AF, patients with coronary artery disease, and patients with ischaemic stroke were significantly lower than that of the age- and sex-matched controls (P < 0.01). One year after successful DCCV, patients with high EPC count (50th to 100th percentile) had a higher recurrence rate of AF when compared with those with low EPC count (less than 50th percentile) (73 vs. 40%, P = 0.02). Cox regression analysis revealed the high EPC count was the only independent predictors for the AF recurrence (HR: 2.29, P = 0.047). The number of EPCs is reduced in patients with persistent AF and predicts the recurrence of AF after successful DCCV.
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/eup382