Effects of Nitric Oxide-Related Compounds and Carperitide on Hemodynamics and Hematocrit in Anesthetized Rats

Sodium nitroprusside, nitroglycerin and carperitide (α-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean bloo...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1992, Vol.59(4), pp.489-492
Main Authors: Aisaka, Kazuo, Miyazaki, Tomoko, Hidaka, Toshinori, Ohno, Tomochika, Ishihara, Takafumi, Kanai, Tadashi
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Atrial Natriuretic Factor - pharmacology
Atrial natriuretic peptide
Biological and medical sciences
Blood Pressure - drug effects
Blood vessels and receptors
Erythrocytes - drug effects
Fundamental and applied biological sciences. Psychology
Heart Rate - drug effects
Hematocrit
Hemodynamics - drug effects
Male
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide - pharmacology
Nitroglycerin - pharmacology
Nitroprusside - pharmacology
omega-N-Methylarginine
Peptide Fragments - pharmacology
Rats
Rats, Wistar
Recombinant Proteins - pharmacology
Vertebrates: cardiovascular system
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Summary:Sodium nitroprusside, nitroglycerin and carperitide (α-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.59.489