Pedicle frozen autograft reconstruction in malignant bone tumors

• Published in: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2010-05, Vol.15 (3), p.340-349
• Main Authors: Tsuchiya, Hiroyuki, Nishida, Hideji, Srisawat, Phutsapong, Shirai, Toshiharu, Hayashi, Katsuhiro, Takeuchi, Akihiko, Yamamoto, Norio, Tomita, Katsuro
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Bone Neoplasms - surgery; Bone Transplantation - methods; Child; Female; Follow-Up Studies; Freezing; Humans; Limb Salvage - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Orthopedics; Osteosarcoma - surgery; Osteotomy - methods; Rheumatology; Specimen Handling - methods; Survival Analysis; Transplantation, Autologous - methods; Young Adult
• ISSN: 0949-2658; 1436-2023
• DOI: 10.1007/s00776-010-1458-0

Standardizing limb salvage surgery for malignant bone tumors should result in improved limb function after tumor excision and reconstruction. Recently, we developed and clinically applied a method of biological reconstruction using tumor-bearing autografts treated with liquid nitrogen. We report this newly modifi ed technique using pedicle frozen autografts to save the continuity of anatomical structures. We treated 33 malignant bone tumor patients. Diagnoses of the tumors were 17 osteosarcomas, 11 metastatic tumors, 2 Ewing’s sarcomas, 2 chondrosarcomas, and 1 undifferentiated pleomorphic sarcoma. The sites of the tumors were 23 femurs, 5 tibias, 4 humeri, and 1 calcaneus. Operative procedures consisted of exposing the tumor, performing one-site osteotomy or joint dislocation, rotating and freezing the tumor lesion in liquid nitrogen for 20 min, and reconstruction using intramedullary nailing, plates, or composite arthroplasty. Postoperative function was excellent in 25 patients (75.7%), good in 5 patients (15.1%), and fair in 3 patients (9.0%). At the fi nal follow-up, 8 patients had died at a mean of 17 months postoperatively, and 18 patients remained disease- free for a mean follow-up period of 30 months (range 7–69 months). Seven patients were alive but with disease. Complications were encountered in 12 patients, including 4 deep infections, 3 fractures, 3 local recurrences from surrounding soft tissue, 2 nonunions, and 1 collapse. All were managed successfully. The pedicle frozen autograft, which was newly developed to solve drawbacks of previously reported free frozen autografts, achieved success for reconstruction of malignant bone tumors. This is a new, simple, effective surgical technique for biological reconstruction that is still investigated but has potential for development.