Childhood and juvenile onset multiple sclerosis: clinical and paraclinical features

It is well known that multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mostly starts in the second to third decade. In the present study, we reviewed our own observations of the clinical and paraclinical features in the 36 of 890 (4.04%) MS patients whose symptom...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2003-06, Vol.25 (4), p.233-236
Main Authors: Ozakbas, Serkan, Idiman, Egemen, Baklan, Baris, Yulug, Burak
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Biological and medical sciences
Child
Childhood
Demographic features
Disease Progression
Humans
Medical sciences
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Prognosis
Retrospective Studies
Sensation Disorders - etiology
Sex Factors
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Summary:It is well known that multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mostly starts in the second to third decade. In the present study, we reviewed our own observations of the clinical and paraclinical features in the 36 of 890 (4.04%) MS patients whose symptoms started before 16 years of age. The average age at onset of the disease in these 36 patients was 12.9 years. In 18 patients, the disease onset was monosymptomatic. Diplopia and sensory disturbances were the most common initial manifestations and occurred in 27.7% of cases. Twenty-one patients (59%) had a relapsing and 11 patients (30.5%) had a secondary progressive course. On the last evaluation, the EDSS score was above 5 in 11 patients and it was below 5 in 21 patients. As a result of this study, we concluded that childhood onset MS does not significantly differ from that it has been typically seen in adults in terms of major clinical manifestations and course of disease.
ISSN:0387-7604
1872-7131
DOI:10.1016/S0387-7604(03)00034-2