Cardiovascular risk factors in polycystic ovary syndrome

A total of 31 women with polycystic ovary syndrome (PCOS) and 31 healthy age/body mass index matched controls were compared for serum hormones, basal and oral-glucose stimulated glucose, insulin, homocysteine, high sensitive C-reactive protein (hsCRP) and lipid levels. The women with PCOS had signif...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2010-05, Vol.30 (4), p.387-392
Main Authors: Karaer, A., Cavkaytar, S., Mert, I., Buyukkagnici, U., Batioglu, S.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Body Mass Index
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular risk
Case-Control Studies
Comparative analysis
Female
Gynecology
homocysteine
Humans
Insulin Resistance
Polycystic ovary syndrome
Polycystic Ovary Syndrome - epidemiology
Prevalence
Risk Factors
Turkey - epidemiology
Women
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Summary:A total of 31 women with polycystic ovary syndrome (PCOS) and 31 healthy age/body mass index matched controls were compared for serum hormones, basal and oral-glucose stimulated glucose, insulin, homocysteine, high sensitive C-reactive protein (hsCRP) and lipid levels. The women with PCOS had significantly higher serum fasting insulin, homocysteine, total cholesterol and LDL cholesterol level than controls, whereas no differences were detected in serum fasting or OGTT 60th- and 120th-minute glucose concentrations, hsCRP, HDL cholesterol, VLDL cholesterol and triglyceride levels between PCOS and control women. Insulin resistance was found in 54.8% (17/31) of PCOS patients by glucose: insulin (G/I) ratio, whereas only 29.0% (9/31) of control women (p = 0.04). Multivariate linear regression analysis revealed that only waist/hip ratio was independent determinants of G/I ratio. PCOS is associated with some biochemical and clinical risk factors for cardiovascular disease. Therefore, patients with PCOS should undergo comprehensive evaluation for recognised cardiovascular risk factors.
ISSN:0144-3615
1364-6893
DOI:10.3109/01443611003763408