ANTENATAL BARTTER SYNDROME: Analysis of Two Cases with Placental Findings

The prenatal diagnosis of Bartter syndrome can be based on the high chloride level in the amniotic fluid. Microscopic examination of the placenta in untreated cases showed extensive mineralization in the chorionic villi in previous studies. Two cases were presented at 26-29 weeks of gestation with s...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2010-05, Vol.29 (3), p.121-126
Main Authors: Dane, Banu, Dane, Cem, Aksoy, Figen, Cetin, Ahmet, Yayla, Murat
Format: Article
Language:English
Subjects:
Adult
Amniocentesis
Amniotic Fluid - chemistry
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arteriosclerosis - complications
Arteriosclerosis - pathology
Bartter syndrome
Bartter Syndrome - complications
Bartter Syndrome - pathology
Bartter Syndrome - therapy
Chlorides - analysis
Chorionic Villi - blood supply
Chorionic Villi - pathology
Female
Fetal Diseases - pathology
Fetal Diseases - therapy
Gestational Age
Humans
Indomethacin - therapeutic use
Infant, Newborn
Male
nephrocalcinosis
Nephrocalcinosis - pathology
Nephrocalcinosis - prevention & control
Placenta Diseases - pathology
Placenta Diseases - therapy
polyhydramnios
Polyhydramnios - etiology
Polyhydramnios - pathology
Polyhydramnios - therapy
Potassium Chloride - therapeutic use
Pregnancy
prenatal diagnosis
Treatment Outcome
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Summary:The prenatal diagnosis of Bartter syndrome can be based on the high chloride level in the amniotic fluid. Microscopic examination of the placenta in untreated cases showed extensive mineralization in the chorionic villi in previous studies. Two cases were presented at 26-29 weeks of gestation with severe polyhydramnios. The mothers were treated with Indomethacin, KCl, and serial amniocentesis in order to reduce the amniotic fluid volume and prevent fetal hypokalemia. The microscopic examination of the placenta revealed focal calcification and acute atherosis in placental vessels. The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis.
ISSN:1551-3815
1551-3823
DOI:10.3109/15513811003777276