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Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate
The components of the molecular codes needed to specify the different neuronal populations present in the basal neural tube are being identified. These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the ex...
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| Published in: | Developmental dynamics 2010-07, Vol.239 (7), p.2094-2101 |
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| container_issue | 7 |
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| container_title | Developmental dynamics |
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| creator | Moreno‐Bravo, Juan Antonio Perez‐Balaguer, Ariadna Martinez, Salvador Puelles, Eduardo |
| description | The components of the molecular codes needed to specify the different neuronal populations present in the basal neural tube are being identified. These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal nuclei of the mesencephalon and diencephalon. The results obtained have shown that there is a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1‐positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei. Developmental Dynamics 239:2094–2101, 2010. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.22327 |
| format | article |
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These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal nuclei of the mesencephalon and diencephalon. The results obtained have shown that there is a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1‐positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei. Developmental Dynamics 239:2094–2101, 2010. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.22327</identifier><identifier>PMID: 20549744</identifier><language>eng</language><publisher>New York: Wiley‐Liss, Inc</publisher><subject>Animals ; basal plate ; development ; Diencephalon - embryology ; Diencephalon - metabolism ; Female ; Gene Expression Regulation, Developmental - genetics ; Gene Expression Regulation, Developmental - physiology ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Immunohistochemistry ; In Situ Hybridization ; interstitial nucleus of Cajal ; Male ; Mesencephalon - embryology ; Mesencephalon - metabolism ; Mice ; Mice, Inbred C57BL ; midbrain ; Nkx6.1 ; Nkx6.2 ; oculomotor nucleus ; Pou4f1 ; Pregnancy ; red nucleus ; rostral interstitial nucleus ; Transcription Factor Brn-3A - genetics ; Transcription Factor Brn-3A - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Developmental dynamics, 2010-07, Vol.239 (7), p.2094-2101</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>(c) 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4307-9676a0cf1a9650ccae3dbe9cfbbbb2af95104bb417b0070d4d5a35aab2b511c03</citedby><cites>FETCH-LOGICAL-c4307-9676a0cf1a9650ccae3dbe9cfbbbb2af95104bb417b0070d4d5a35aab2b511c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20549744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno‐Bravo, Juan Antonio</creatorcontrib><creatorcontrib>Perez‐Balaguer, Ariadna</creatorcontrib><creatorcontrib>Martinez, Salvador</creatorcontrib><creatorcontrib>Puelles, Eduardo</creatorcontrib><title>Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>The components of the molecular codes needed to specify the different neuronal populations present in the basal neural tube are being identified. These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal nuclei of the mesencephalon and diencephalon. The results obtained have shown that there is a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1‐positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei. Developmental Dynamics 239:2094–2101, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>basal plate</subject><subject>development</subject><subject>Diencephalon - embryology</subject><subject>Diencephalon - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>interstitial nucleus of Cajal</subject><subject>Male</subject><subject>Mesencephalon - embryology</subject><subject>Mesencephalon - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>midbrain</subject><subject>Nkx6.1</subject><subject>Nkx6.2</subject><subject>oculomotor nucleus</subject><subject>Pou4f1</subject><subject>Pregnancy</subject><subject>red nucleus</subject><subject>rostral interstitial nucleus</subject><subject>Transcription Factor Brn-3A - genetics</subject><subject>Transcription Factor Brn-3A - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOxDAQRS0E4rHQ8AHIHRJSlnGcxEmJdnlJCBpAoorG9gQCeRFnF7bjE_hGvoQsWSiZZm5xdIrD2L6AsQDwj-3cLsa-L321xrYFJMoDodT6coexF8s43mI7zj0DQBwFYpNt-RAGiQqCbYbTRYVlbji9Ny05l9cVb7DrqK0crzN-_fIejQXHyg7T53nFuyfiluZU1E1ePfKS3NfHp82pMtQ8YdHbNDoseFNgR7tsI8PC0d7qj9jd2ent5MK7ujm_nJxceSaQoLwkUhGCyQQmUQjGIEmrKTGZ7s_HLAkFBFoHQmkABTawIcoQUfs6FMKAHLHDwdu09euMXJeWuTNUFFhRPXOpklIKkGHck0cDadrauZaytGnzEttFKiBdFk2XRdOfoj18sNLOdEn2D_1N2ANiAN7yghb_qNLp_fRhkH4Dk6KCbw</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Moreno‐Bravo, Juan Antonio</creator><creator>Perez‐Balaguer, Ariadna</creator><creator>Martinez, Salvador</creator><creator>Puelles, Eduardo</creator><general>Wiley‐Liss, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate</title><author>Moreno‐Bravo, Juan Antonio ; Perez‐Balaguer, Ariadna ; Martinez, Salvador ; Puelles, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4307-9676a0cf1a9650ccae3dbe9cfbbbb2af95104bb417b0070d4d5a35aab2b511c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>basal plate</topic><topic>development</topic><topic>Diencephalon - embryology</topic><topic>Diencephalon - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>interstitial nucleus of Cajal</topic><topic>Male</topic><topic>Mesencephalon - embryology</topic><topic>Mesencephalon - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>midbrain</topic><topic>Nkx6.1</topic><topic>Nkx6.2</topic><topic>oculomotor nucleus</topic><topic>Pou4f1</topic><topic>Pregnancy</topic><topic>red nucleus</topic><topic>rostral interstitial nucleus</topic><topic>Transcription Factor Brn-3A - genetics</topic><topic>Transcription Factor Brn-3A - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno‐Bravo, Juan Antonio</creatorcontrib><creatorcontrib>Perez‐Balaguer, Ariadna</creatorcontrib><creatorcontrib>Martinez, Salvador</creatorcontrib><creatorcontrib>Puelles, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno‐Bravo, Juan Antonio</au><au>Perez‐Balaguer, Ariadna</au><au>Martinez, Salvador</au><au>Puelles, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2010-07</date><risdate>2010</risdate><volume>239</volume><issue>7</issue><spage>2094</spage><epage>2101</epage><pages>2094-2101</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>The components of the molecular codes needed to specify the different neuronal populations present in the basal neural tube are being identified. These codes become more intricate as we move to more anterior regions of the central nervous system. The aim of this study is to thoroughly analyze the expression pattern of Nkx6.1, Nkx6.2, and Pou4f1. These three genes are candidates to play an important role in the determination and differentiation of the basal nuclei of the mesencephalon and diencephalon. The results obtained have shown that there is a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1‐positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei. 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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals basal plate development Diencephalon - embryology Diencephalon - metabolism Female Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Immunohistochemistry In Situ Hybridization interstitial nucleus of Cajal Male Mesencephalon - embryology Mesencephalon - metabolism Mice Mice, Inbred C57BL midbrain Nkx6.1 Nkx6.2 oculomotor nucleus Pou4f1 Pregnancy red nucleus rostral interstitial nucleus Transcription Factor Brn-3A - genetics Transcription Factor Brn-3A - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate |
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