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Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins
Aim The aim of this study was to compare the effects of exercise on plasma glucose excursions when using each of three basal insulins in people with Type 1 diabetes. Research design and methods This was a multinational, open‐label, randomized, three‐period, crossover clinical trial. People with Ty...
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| Published in: | Diabetic medicine 2009-10, Vol.26 (10), p.1027-1032 |
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| container_title | Diabetic medicine |
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| creator | Arutchelvam, V. Heise, T. Dellweg, S. Elbroend, B. Minns, I. Home, P. D. |
| description | Aim The aim of this study was to compare the effects of exercise on plasma glucose excursions when using each of three basal insulins in people with Type 1 diabetes.
Research design and methods This was a multinational, open‐label, randomized, three‐period, crossover clinical trial. People with Type 1 diabetes [n = 51, age 39 ± 10 (± sd) years, 67% men] managed with mealtime plus basal insulin regimens, were exercised for 30 min, 5 h after the last mealtime and basal insulin injection when using insulin detemir, insulin glargine or neutral protamine Hagedorn (NPH) insulin.
Results There were no significant differences in the plasma glucose excursions during or for 150 min after exercise. During 30 min exercise, five (11%) participants on insulin detemir developed minor hypoglycaemia, six (12%) for NPH and 18 (38%) for glargine. From the end of exercise to 150 min, five (11%) on insulin detemir developed minor hypoglycaemia, seven (14%) for NPH and nine (19%) for glargine. In total, from start of exercise to 150 min after exercise, 10 (21%) participants on insulin detemir experienced minor hypoglycaemia as compared with 13 (27%) for NPH and 27 (57%) for glargine (P |
| doi_str_mv | 10.1111/j.1464-5491.2009.02807.x |
| format | article |
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Research design and methods This was a multinational, open‐label, randomized, three‐period, crossover clinical trial. People with Type 1 diabetes [n = 51, age 39 ± 10 (± sd) years, 67% men] managed with mealtime plus basal insulin regimens, were exercised for 30 min, 5 h after the last mealtime and basal insulin injection when using insulin detemir, insulin glargine or neutral protamine Hagedorn (NPH) insulin.
Results There were no significant differences in the plasma glucose excursions during or for 150 min after exercise. During 30 min exercise, five (11%) participants on insulin detemir developed minor hypoglycaemia, six (12%) for NPH and 18 (38%) for glargine. From the end of exercise to 150 min, five (11%) on insulin detemir developed minor hypoglycaemia, seven (14%) for NPH and nine (19%) for glargine. In total, from start of exercise to 150 min after exercise, 10 (21%) participants on insulin detemir experienced minor hypoglycaemia as compared with 13 (27%) for NPH and 27 (57%) for glargine (P < 0.001 glargine vs. detemir and NPH). Maximum plasma cortisol levels were lower on detemir and NPH than glargine.
Conclusions Insulin detemir was associated with less hypoglycaemia than insulin glargine but not NPH insulin in relatively well‐controlled people with Type 1 diabetes during and after exercise.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2009.02807.x</identifier><identifier>PMID: 19900235</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Glucose - metabolism ; Cross-Over Studies ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; exercise ; Exercise - physiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - analogs & derivatives ; Insulin - therapeutic use ; Insulin Detemir ; Insulin Glargine ; Insulin, Isophane - therapeutic use ; Insulin, Long-Acting ; Male ; Medical sciences ; Middle Aged ; NPH insulin ; Treatment Outcome ; Type 1 diabetes ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Diabetic medicine, 2009-10, Vol.26 (10), p.1027-1032</ispartof><rights>2009 The Authors. Journal compilation © 2009 Diabetes UK</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4677-2f97b09cb1184b23bfd01c32e98383f211a3c9c7fab9cf4d228b6b2d8341df893</citedby><cites>FETCH-LOGICAL-c4677-2f97b09cb1184b23bfd01c32e98383f211a3c9c7fab9cf4d228b6b2d8341df893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22005704$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19900235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arutchelvam, V.</creatorcontrib><creatorcontrib>Heise, T.</creatorcontrib><creatorcontrib>Dellweg, S.</creatorcontrib><creatorcontrib>Elbroend, B.</creatorcontrib><creatorcontrib>Minns, I.</creatorcontrib><creatorcontrib>Home, P. D.</creatorcontrib><title>Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aim The aim of this study was to compare the effects of exercise on plasma glucose excursions when using each of three basal insulins in people with Type 1 diabetes.
Research design and methods This was a multinational, open‐label, randomized, three‐period, crossover clinical trial. People with Type 1 diabetes [n = 51, age 39 ± 10 (± sd) years, 67% men] managed with mealtime plus basal insulin regimens, were exercised for 30 min, 5 h after the last mealtime and basal insulin injection when using insulin detemir, insulin glargine or neutral protamine Hagedorn (NPH) insulin.
Results There were no significant differences in the plasma glucose excursions during or for 150 min after exercise. During 30 min exercise, five (11%) participants on insulin detemir developed minor hypoglycaemia, six (12%) for NPH and 18 (38%) for glargine. From the end of exercise to 150 min, five (11%) on insulin detemir developed minor hypoglycaemia, seven (14%) for NPH and nine (19%) for glargine. In total, from start of exercise to 150 min after exercise, 10 (21%) participants on insulin detemir experienced minor hypoglycaemia as compared with 13 (27%) for NPH and 27 (57%) for glargine (P < 0.001 glargine vs. detemir and NPH). Maximum plasma cortisol levels were lower on detemir and NPH than glargine.
Conclusions Insulin detemir was associated with less hypoglycaemia than insulin glargine but not NPH insulin in relatively well‐controlled people with Type 1 diabetes during and after exercise.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cross-Over Studies</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>exercise</subject><subject>Exercise - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - analogs & derivatives</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Detemir</subject><subject>Insulin Glargine</subject><subject>Insulin, Isophane - therapeutic use</subject><subject>Insulin, Long-Acting</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NPH insulin</subject><subject>Treatment Outcome</subject><subject>Type 1 diabetes</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkVuP1CAYhonRuOPqXzDcqFetHDpDMfFisyeN6ylZY-INAQozjLRUaDOdfy91JuOdkRAg4Xm-j_ACADEqcR6vtyWuVlWxrDguCUK8RKRGrJwegMXp4iFYIFaRgiKGz8CTlLYIYcIpfwzOMOcIEbpcgOmLl6mVcO1HHZKBsmvgZt-Htd9raVonoQ3eh53r1tBMJmqXIdfB3oTeG7hzwwbe73sDMWycVGYw6Q2UUIe2l9Gl0MFg4bCJxkAlk_TZTaPPy1PwyEqfzLPjfg6-3VzfX74r7j7fvr-8uCt0tWKsIJYzhbhWGNeVIlTZBmFNieE1raklGEuquWZWKq5t1RBSq5UiTU0r3Nia03Pw6lC3j-HXaNIgWpe08V52JoxJMEopznMmX_6TzL1ofgXOYH0AdQwpRWNFH10r415gJOZ8xFbMMYg5BjHnI_7kI6asPj_2GFVrmr_iMZAMvDgCMmnpbZRd_vITR3K1JUNV5t4euJ3zZv_fDxBXH6_nU_aLg-_SYKaTL-NPsWKULcX3T7fi64cr9KO-QQLR30mzuz8</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Arutchelvam, V.</creator><creator>Heise, T.</creator><creator>Dellweg, S.</creator><creator>Elbroend, B.</creator><creator>Minns, I.</creator><creator>Home, P. D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200910</creationdate><title>Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins</title><author>Arutchelvam, V. ; Heise, T. ; Dellweg, S. ; Elbroend, B. ; Minns, I. ; Home, P. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4677-2f97b09cb1184b23bfd01c32e98383f211a3c9c7fab9cf4d228b6b2d8341df893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cross-Over Studies</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>exercise</topic><topic>Exercise - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - analogs & derivatives</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Detemir</topic><topic>Insulin Glargine</topic><topic>Insulin, Isophane - therapeutic use</topic><topic>Insulin, Long-Acting</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NPH insulin</topic><topic>Treatment Outcome</topic><topic>Type 1 diabetes</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arutchelvam, V.</creatorcontrib><creatorcontrib>Heise, T.</creatorcontrib><creatorcontrib>Dellweg, S.</creatorcontrib><creatorcontrib>Elbroend, B.</creatorcontrib><creatorcontrib>Minns, I.</creatorcontrib><creatorcontrib>Home, P. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arutchelvam, V.</au><au>Heise, T.</au><au>Dellweg, S.</au><au>Elbroend, B.</au><au>Minns, I.</au><au>Home, P. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2009-10</date><risdate>2009</risdate><volume>26</volume><issue>10</issue><spage>1027</spage><epage>1032</epage><pages>1027-1032</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aim The aim of this study was to compare the effects of exercise on plasma glucose excursions when using each of three basal insulins in people with Type 1 diabetes.
Research design and methods This was a multinational, open‐label, randomized, three‐period, crossover clinical trial. People with Type 1 diabetes [n = 51, age 39 ± 10 (± sd) years, 67% men] managed with mealtime plus basal insulin regimens, were exercised for 30 min, 5 h after the last mealtime and basal insulin injection when using insulin detemir, insulin glargine or neutral protamine Hagedorn (NPH) insulin.
Results There were no significant differences in the plasma glucose excursions during or for 150 min after exercise. During 30 min exercise, five (11%) participants on insulin detemir developed minor hypoglycaemia, six (12%) for NPH and 18 (38%) for glargine. From the end of exercise to 150 min, five (11%) on insulin detemir developed minor hypoglycaemia, seven (14%) for NPH and nine (19%) for glargine. In total, from start of exercise to 150 min after exercise, 10 (21%) participants on insulin detemir experienced minor hypoglycaemia as compared with 13 (27%) for NPH and 27 (57%) for glargine (P < 0.001 glargine vs. detemir and NPH). Maximum plasma cortisol levels were lower on detemir and NPH than glargine.
Conclusions Insulin detemir was associated with less hypoglycaemia than insulin glargine but not NPH insulin in relatively well‐controlled people with Type 1 diabetes during and after exercise.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19900235</pmid><doi>10.1111/j.1464-5491.2009.02807.x</doi><tpages>6</tpages></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Blood Glucose - metabolism Cross-Over Studies Diabetes Mellitus, Type 1 - drug therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance exercise Exercise - physiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Hypoglycemic Agents - therapeutic use Insulin - analogs & derivatives Insulin - therapeutic use Insulin Detemir Insulin Glargine Insulin, Isophane - therapeutic use Insulin, Long-Acting Male Medical sciences Middle Aged NPH insulin Treatment Outcome Type 1 diabetes Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Young Adult |
| title | Plasma glucose and hypoglycaemia following exercise in people with Type 1 diabetes: a comparison of three basal insulins |
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