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Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma
Background. Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers. Because little was known about the significance of SCC-Ag concentration in patients with esophageal c...
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| Published in: | Surgery 2003-05, Vol.133 (5), p.486-494 |
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| container_end_page | 494 |
| container_issue | 5 |
| container_start_page | 486 |
| container_title | Surgery |
| container_volume | 133 |
| creator | Shimada, Hideaki Nabeya, Yoshihiro Okazumi, Shin-ichi Matsubara, Hisahiro Shiratori, Tooru Gunji, Yoshio Kobayashi, Susumu Hayashi, Hideki Ochiai, Takenori |
| description | Background. Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers. Because little was known about the significance of SCC-Ag concentration in patients with esophageal cancer, the aim of this study was to analyze the clinicopathologic significance of SCC-Ag in patients with esophageal SCC. Patients and Methods. Preoperative SCC-Ag concentration was measured with enzyme-linked immunosorbent assay in 309 patients with primary esophageal SCC. All patients underwent curative radical surgery without any preoperative therapy. In 215 of 309 patients, carcinoembryonic antigen (CEA) was also measured to compare clinical significance of CEA with that of SCC-Ag. The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model. Results. The SCC-Ag concentration and the positivity rate of SCC-Ag were significantly elevated in patients associated with tumor progression. Statistically significant differences in SCC-Ag concentrations and SCC-Ag positivity rates were observed depending on tumor size, tumor depth, lymph node status, and distant metastasis. Although CEA was not a prognostic factor (P =.21), a high SCC-Ag concentration was a significant prognostic factor (P |
| doi_str_mv | 10.1067/msy.2003.139 |
| format | article |
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Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers. Because little was known about the significance of SCC-Ag concentration in patients with esophageal cancer, the aim of this study was to analyze the clinicopathologic significance of SCC-Ag in patients with esophageal SCC. Patients and Methods. Preoperative SCC-Ag concentration was measured with enzyme-linked immunosorbent assay in 309 patients with primary esophageal SCC. All patients underwent curative radical surgery without any preoperative therapy. In 215 of 309 patients, carcinoembryonic antigen (CEA) was also measured to compare clinical significance of CEA with that of SCC-Ag. The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model. Results. The SCC-Ag concentration and the positivity rate of SCC-Ag were significantly elevated in patients associated with tumor progression. Statistically significant differences in SCC-Ag concentrations and SCC-Ag positivity rates were observed depending on tumor size, tumor depth, lymph node status, and distant metastasis. Although CEA was not a prognostic factor (P =.21), a high SCC-Ag concentration was a significant prognostic factor (P <.01). Multivariate analyses indicated that T factor had the best predictive power, but SCC-Ag concentration contained additional, independent prognostic information. Conclusion. Our findings suggest that preoperative serum SCC-Ag concentrations might provide a predictive information for tumor progression and survival in patients with esophageal SCC. (Surgery 2003;133:486-94.)</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1067/msy.2003.139</identifier><identifier>PMID: 12773976</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, Neoplasm - analysis ; Biological and medical sciences ; Carcinoembryonic Antigen - analysis ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Disease Progression ; Esophageal Neoplasms - immunology ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Lymph Node Excision ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Osmolar Concentration ; Postoperative Period ; Prognosis ; Serpins ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Analysis ; Tumors</subject><ispartof>Surgery, 2003-05, Vol.133 (5), p.486-494</ispartof><rights>2003 Mosby, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-9aab72743931042228c08cbdb8dc3ea0742334c98dc46c55268d10ab18277c663</citedby><cites>FETCH-LOGICAL-c364t-9aab72743931042228c08cbdb8dc3ea0742334c98dc46c55268d10ab18277c663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14876642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12773976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimada, Hideaki</creatorcontrib><creatorcontrib>Nabeya, Yoshihiro</creatorcontrib><creatorcontrib>Okazumi, Shin-ichi</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Shiratori, Tooru</creatorcontrib><creatorcontrib>Gunji, Yoshio</creatorcontrib><creatorcontrib>Kobayashi, Susumu</creatorcontrib><creatorcontrib>Hayashi, Hideki</creatorcontrib><creatorcontrib>Ochiai, Takenori</creatorcontrib><title>Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background. Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers. Because little was known about the significance of SCC-Ag concentration in patients with esophageal cancer, the aim of this study was to analyze the clinicopathologic significance of SCC-Ag in patients with esophageal SCC. Patients and Methods. Preoperative SCC-Ag concentration was measured with enzyme-linked immunosorbent assay in 309 patients with primary esophageal SCC. All patients underwent curative radical surgery without any preoperative therapy. In 215 of 309 patients, carcinoembryonic antigen (CEA) was also measured to compare clinical significance of CEA with that of SCC-Ag. The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model. Results. The SCC-Ag concentration and the positivity rate of SCC-Ag were significantly elevated in patients associated with tumor progression. Statistically significant differences in SCC-Ag concentrations and SCC-Ag positivity rates were observed depending on tumor size, tumor depth, lymph node status, and distant metastasis. Although CEA was not a prognostic factor (P =.21), a high SCC-Ag concentration was a significant prognostic factor (P <.01). Multivariate analyses indicated that T factor had the best predictive power, but SCC-Ag concentration contained additional, independent prognostic information. Conclusion. Our findings suggest that preoperative serum SCC-Ag concentrations might provide a predictive information for tumor progression and survival in patients with esophageal SCC. (Surgery 2003;133:486-94.)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Disease Progression</subject><subject>Esophageal Neoplasms - immunology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Osmolar Concentration</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Serpins</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp1kU1vEzEQhi0Eomngxhn5Aqdu8Ffs3SOq-JIqwQHO1uzspDXaj9Szm6r8ehwlUi9wsmb0-NXrx0K80WqjlQ8fBn7cGKXsRtvmmVjprTVVsF4_F6uybSqvvLoQl8y_lVKN0_VLcaFNCLYJfiX-_MjUJZzTNMppJ3nJh3SAXj6k-U7y_QLDtLBE6nuJkDGN0wASxjnd0ijTKPcwJxpnPl3IxIQztD1J4ml_B7dUsv4T80q82EHP9Pp8rsWvz59-Xn-tbr5_-Xb98aZC691cNQBtMMHZxmrljDE1qhrbrq07tAQqOGOtw6aMzuN2a3zdaQWtrssj0Xu7Fu9Pufs83S_EcxwSH6vASKVVDNZabd0RvDqBmCfmTLu4z2mA_Bi1ikfXsbiOR9exuC7423Pu0g7UPcFnuQV4dwaAEfpdhhETP3GuDt6X9mvhTxwVC4dEOTIWqVg-JhedsZvSvxv8BeQvm-Q</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Shimada, Hideaki</creator><creator>Nabeya, Yoshihiro</creator><creator>Okazumi, Shin-ichi</creator><creator>Matsubara, Hisahiro</creator><creator>Shiratori, Tooru</creator><creator>Gunji, Yoshio</creator><creator>Kobayashi, Susumu</creator><creator>Hayashi, Hideki</creator><creator>Ochiai, Takenori</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma</title><author>Shimada, Hideaki ; Nabeya, Yoshihiro ; Okazumi, Shin-ichi ; Matsubara, Hisahiro ; Shiratori, Tooru ; Gunji, Yoshio ; Kobayashi, Susumu ; Hayashi, Hideki ; Ochiai, Takenori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-9aab72743931042228c08cbdb8dc3ea0742334c98dc46c55268d10ab18277c663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Biological and medical sciences</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Disease Progression</topic><topic>Esophageal Neoplasms - immunology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Osmolar Concentration</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Serpins</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimada, Hideaki</creatorcontrib><creatorcontrib>Nabeya, Yoshihiro</creatorcontrib><creatorcontrib>Okazumi, Shin-ichi</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Shiratori, Tooru</creatorcontrib><creatorcontrib>Gunji, Yoshio</creatorcontrib><creatorcontrib>Kobayashi, Susumu</creatorcontrib><creatorcontrib>Hayashi, Hideki</creatorcontrib><creatorcontrib>Ochiai, Takenori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimada, Hideaki</au><au>Nabeya, Yoshihiro</au><au>Okazumi, Shin-ichi</au><au>Matsubara, Hisahiro</au><au>Shiratori, Tooru</au><au>Gunji, Yoshio</au><au>Kobayashi, Susumu</au><au>Hayashi, Hideki</au><au>Ochiai, Takenori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>133</volume><issue>5</issue><spage>486</spage><epage>494</epage><pages>486-494</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background. Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers. Because little was known about the significance of SCC-Ag concentration in patients with esophageal cancer, the aim of this study was to analyze the clinicopathologic significance of SCC-Ag in patients with esophageal SCC. Patients and Methods. Preoperative SCC-Ag concentration was measured with enzyme-linked immunosorbent assay in 309 patients with primary esophageal SCC. All patients underwent curative radical surgery without any preoperative therapy. In 215 of 309 patients, carcinoembryonic antigen (CEA) was also measured to compare clinical significance of CEA with that of SCC-Ag. The prognostic significance for survival of SCC-Ag concentrations was studied with multivariate analysis with Cox proportional hazards model. Results. The SCC-Ag concentration and the positivity rate of SCC-Ag were significantly elevated in patients associated with tumor progression. Statistically significant differences in SCC-Ag concentrations and SCC-Ag positivity rates were observed depending on tumor size, tumor depth, lymph node status, and distant metastasis. Although CEA was not a prognostic factor (P =.21), a high SCC-Ag concentration was a significant prognostic factor (P <.01). Multivariate analyses indicated that T factor had the best predictive power, but SCC-Ag concentration contained additional, independent prognostic information. Conclusion. Our findings suggest that preoperative serum SCC-Ag concentrations might provide a predictive information for tumor progression and survival in patients with esophageal SCC. (Surgery 2003;133:486-94.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>12773976</pmid><doi>10.1067/msy.2003.139</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigens, Neoplasm - analysis Biological and medical sciences Carcinoembryonic Antigen - analysis Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Disease Progression Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagectomy Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Lymph Node Excision Male Medical sciences Middle Aged Neoplasm Staging Osmolar Concentration Postoperative Period Prognosis Serpins Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis Tumors |
| title | Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma |
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