Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: Social factors are important predictors after adjusting for known risk factors

To monitor the prevalence of hepatitis B and hepatitis C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design was used to enroll 14,416 adult participants aged 18-80 years. Data collected included demographic and social characteristics and ris...

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Bibliographic Details
Published in:Journal of medical virology 2010-04, Vol.82 (4), p.546-555
Main Authors: Meffre, Christine, Le Strat, Yann, Delarocque-Astagneau, Elisabeth, Dubois, Fréderic, Antona, Denise, Lemasson, Jean-Marie, Warszawski, Josiane, Steinmetz, Josiane, Coste, Dominique, Meyer, Jean-François, Leiser, Sandrine, Giordanella, Jean-Pierre, Gueguen, René, Desenclos, Jean-Claude
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
chronic hepatitis B and C
Cross-Sectional Studies
cross-sectional study
Epidemiology
Female
France - epidemiology
Fundamental and applied biological sciences. Psychology
Hepatitis B - epidemiology
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Hepatitis C - epidemiology
Hepatitis C Antibodies - blood
Hepatitis C virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Prevalence
Risk Factors
RNA, Viral - blood
Socioeconomic Factors
Urban Population
Viral diseases
Viral hepatitis
Virology
Young Adult
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Summary:To monitor the prevalence of hepatitis B and hepatitis C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design was used to enroll 14,416 adult participants aged 18-80 years. Data collected included demographic and social characteristics and risk factors. Sera were tested for anti-HCV, HCV-RNA, anti-HBc and HBsAg. Data were analyzed with SUDAAN® software to provide weighted estimates for the French metropolitan resident population. The overall anti-HCV prevalence was 0.84% (95% CI: 0.65-1.10). Among anti-HCV positive individuals, 57.4% (95% CI: 43.2-70.5) knew their status. Factors associated independently with positive anti-HCV were drug use (intravenous and nasal), blood transfusion before 1992, a history of tattoos, low socioeconomic status, being born in a country where anti-HCV prevalence >2.5%, and age >29 years. The overall anti-HBc prevalence was 7.3% (95%: 6.5-8.2). Independent risk factors for anti-HBc were intravenous drug use, being a man who has sex with men, low socioeconomic status, a stay in a psychiatric facility or facility for the mentally disabled, 2%, age >29 and male sex. The HCV RNA and HBsAg prevalence were 0.53% (95% CI: 0.40-0.70) and 0.65% (95% CI: 0.45-0.93), respectively. Among HBsAg positive individuals, 44.8% (95% CI: 22.8-69.1) knew their status. Anti-HCV prevalence was close to the 1990s estimates whereas HBsAg prevalence estimate was greater than expected. Screening of hepatitis B and C should be strengthened and should account for social vulnerability. J. Med. Virol. 82:546-555, 2010.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21734