Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study

The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concent...

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Bibliographic Details
Published in:Biomarkers 2010-06, Vol.15 (4), p.332-339
Main Authors: Liang, Xin-Ling, Liu, Shuang-Xin, Chen, Yuan-Han, Yan, Li-Jun, Li, Heng, Xuan, Hui-Jie, Liang, Yong-Zheng, Shi, Wei
Format: Article
Language:English
Subjects:
Acute Disease
Acute kidney injury
Adult
biomarker
Biomarkers - urine
cardiopulmonary bypass
Cardiopulmonary Bypass - adverse effects
Case-Control Studies
Disease Progression
Early Diagnosis
Hepatitis A Virus Cellular Receptor 1
Humans
interleukin-18 (IL-18)
Interleukin-18 - urine
Kidney Diseases - diagnosis
Kidney Diseases - epidemiology
Kidney Diseases - etiology
kidney injury molecule-1 (Kim-1)
Membrane Glycoproteins - urine
Middle Aged
Receptors, Virus
Young Adult
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Summary:The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.
ISSN:1354-750X
1366-5804
DOI:10.3109/13547501003706558