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N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents
The new complexes M(DMBG) 2(ClO 4) 2 (M:Mn, Ni, Cu and Zn; DMBG: N, N-dimethylbiguanide) have been synthesized and characterized by IR, EPR, 1H NMR, 13C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG) 2](ClO 4) 2·2DMF (DMF: N, N-dimethylformamide) crystallizes in the monoclinic P2(1)/...
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| Published in: | European journal of medicinal chemistry 2010-07, Vol.45 (7), p.3027-3034 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 3034 |
| container_issue | 7 |
| container_start_page | 3027 |
| container_title | European journal of medicinal chemistry |
| container_volume | 45 |
| creator | Olar, Rodica Badea, Mihaela Marinescu, Dana Chifiriuc, Mariana-Carmen Bleotu, Coralia Grecu, Maria Nicoleta Iorgulescu, Emilia-Elena Lazar, Veronica |
| description | The new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesized and characterized by IR, EPR,
1H NMR,
13C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)
2](ClO
4)
2·2DMF (DMF:
N,
N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)
2](ClO
4)
2 adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free
N,
N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of
Pseudomonas aeruginosa and
Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.
A series of new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesised and evaluated for their antimicrobial, antibiofilm as well as cytostatic activity.
[Display omitted] |
| doi_str_mv | 10.1016/j.ejmech.2010.03.033 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733316458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0223523410002473</els_id><sourcerecordid>733316458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-2a37104e0565d00af8b3161900b94c745dc5edcb37389170bd2afeddfe9a16d43</originalsourceid><addsrcrecordid>eNp9kElrHDEQRkWIiSdO_kEIuoRc3OPS0tslYEw2MPbFOQu1VD3WoF4iqR33v4-GmSS3QIGg9Krq4xHyjsGWAauu9lvcD2getxxyC0Qu8YJsWF01heClfEk2wLkoSi7kOXkd4x4AygrgFTnnIEFUst6Q4e6S3hXWDZgeV9-53aJHZ5GaaZg9PmOk1sXZ69WNO-qnX9SsaUrTszMurVRHOk8Jx-S0p16HHdI4o0lhGajO3cGZMHWHT73LVHxDznrtI749vRfkx5fPDzffitv7r99vrm8LI1qWCq5FzUBijltaAN03nWAVawG6VppaltaUaE0natG0rIbOct2jtT22mlVWigvy8bh3DtPPBWNSg4sGvdcjTktUtRB5oSybTMojmYPGGLBXc3CDDqtioA6e1V4dPauDZwUil8hj708Hlm5A-3foj9gMfDgBOhrt-6BH4-I_jje85c3h_qcjh1nHk8OgonE4GrQuZJHKTu7_SX4DUFKfgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733316458</pqid></control><display><type>article</type><title>N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents</title><source>Elsevier</source><creator>Olar, Rodica ; Badea, Mihaela ; Marinescu, Dana ; Chifiriuc, Mariana-Carmen ; Bleotu, Coralia ; Grecu, Maria Nicoleta ; Iorgulescu, Emilia-Elena ; Lazar, Veronica</creator><creatorcontrib>Olar, Rodica ; Badea, Mihaela ; Marinescu, Dana ; Chifiriuc, Mariana-Carmen ; Bleotu, Coralia ; Grecu, Maria Nicoleta ; Iorgulescu, Emilia-Elena ; Lazar, Veronica</creatorcontrib><description>The new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesized and characterized by IR, EPR,
1H NMR,
13C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)
2](ClO
4)
2·2DMF (DMF:
N,
N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)
2](ClO
4)
2 adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free
N,
N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of
Pseudomonas aeruginosa and
Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.
A series of new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesised and evaluated for their antimicrobial, antibiofilm as well as cytostatic activity.
[Display omitted]</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2010.03.033</identifier><identifier>PMID: 20403647</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - toxicity ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial activity ; Bacteria - drug effects ; Bacterial biofilm ; Biological and medical sciences ; Complex ; Crystallography, X-Ray ; Cytotoxicity ; Electrochemistry ; Fungi - drug effects ; General aspects ; HeLa Cells ; Humans ; Medical sciences ; Metformin - chemistry ; Metformin - pharmacology ; Metformin - toxicity ; N,N-dimethylbiguanide ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Organometallic Compounds - toxicity ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Spectrum Analysis ; Stereoisomerism</subject><ispartof>European journal of medicinal chemistry, 2010-07, Vol.45 (7), p.3027-3034</ispartof><rights>2010 Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-2a37104e0565d00af8b3161900b94c745dc5edcb37389170bd2afeddfe9a16d43</citedby><cites>FETCH-LOGICAL-c391t-2a37104e0565d00af8b3161900b94c745dc5edcb37389170bd2afeddfe9a16d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22829288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20403647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olar, Rodica</creatorcontrib><creatorcontrib>Badea, Mihaela</creatorcontrib><creatorcontrib>Marinescu, Dana</creatorcontrib><creatorcontrib>Chifiriuc, Mariana-Carmen</creatorcontrib><creatorcontrib>Bleotu, Coralia</creatorcontrib><creatorcontrib>Grecu, Maria Nicoleta</creatorcontrib><creatorcontrib>Iorgulescu, Emilia-Elena</creatorcontrib><creatorcontrib>Lazar, Veronica</creatorcontrib><title>N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>The new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesized and characterized by IR, EPR,
1H NMR,
13C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)
2](ClO
4)
2·2DMF (DMF:
N,
N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)
2](ClO
4)
2 adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free
N,
N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of
Pseudomonas aeruginosa and
Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.
A series of new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesised and evaluated for their antimicrobial, antibiofilm as well as cytostatic activity.
[Display omitted]</description><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - toxicity</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial activity</subject><subject>Bacteria - drug effects</subject><subject>Bacterial biofilm</subject><subject>Biological and medical sciences</subject><subject>Complex</subject><subject>Crystallography, X-Ray</subject><subject>Cytotoxicity</subject><subject>Electrochemistry</subject><subject>Fungi - drug effects</subject><subject>General aspects</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metformin - chemistry</subject><subject>Metformin - pharmacology</subject><subject>Metformin - toxicity</subject><subject>N,N-dimethylbiguanide</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Organometallic Compounds - toxicity</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrum Analysis</subject><subject>Stereoisomerism</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kElrHDEQRkWIiSdO_kEIuoRc3OPS0tslYEw2MPbFOQu1VD3WoF4iqR33v4-GmSS3QIGg9Krq4xHyjsGWAauu9lvcD2getxxyC0Qu8YJsWF01heClfEk2wLkoSi7kOXkd4x4AygrgFTnnIEFUst6Q4e6S3hXWDZgeV9-53aJHZ5GaaZg9PmOk1sXZ69WNO-qnX9SsaUrTszMurVRHOk8Jx-S0p16HHdI4o0lhGajO3cGZMHWHT73LVHxDznrtI749vRfkx5fPDzffitv7r99vrm8LI1qWCq5FzUBijltaAN03nWAVawG6VppaltaUaE0natG0rIbOct2jtT22mlVWigvy8bh3DtPPBWNSg4sGvdcjTktUtRB5oSybTMojmYPGGLBXc3CDDqtioA6e1V4dPauDZwUil8hj708Hlm5A-3foj9gMfDgBOhrt-6BH4-I_jje85c3h_qcjh1nHk8OgonE4GrQuZJHKTu7_SX4DUFKfgw</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Olar, Rodica</creator><creator>Badea, Mihaela</creator><creator>Marinescu, Dana</creator><creator>Chifiriuc, Mariana-Carmen</creator><creator>Bleotu, Coralia</creator><creator>Grecu, Maria Nicoleta</creator><creator>Iorgulescu, Emilia-Elena</creator><creator>Lazar, Veronica</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents</title><author>Olar, Rodica ; Badea, Mihaela ; Marinescu, Dana ; Chifiriuc, Mariana-Carmen ; Bleotu, Coralia ; Grecu, Maria Nicoleta ; Iorgulescu, Emilia-Elena ; Lazar, Veronica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-2a37104e0565d00af8b3161900b94c745dc5edcb37389170bd2afeddfe9a16d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - toxicity</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobial activity</topic><topic>Bacteria - drug effects</topic><topic>Bacterial biofilm</topic><topic>Biological and medical sciences</topic><topic>Complex</topic><topic>Crystallography, X-Ray</topic><topic>Cytotoxicity</topic><topic>Electrochemistry</topic><topic>Fungi - drug effects</topic><topic>General aspects</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metformin - chemistry</topic><topic>Metformin - pharmacology</topic><topic>Metformin - toxicity</topic><topic>N,N-dimethylbiguanide</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Organometallic Compounds - toxicity</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrum Analysis</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olar, Rodica</creatorcontrib><creatorcontrib>Badea, Mihaela</creatorcontrib><creatorcontrib>Marinescu, Dana</creatorcontrib><creatorcontrib>Chifiriuc, Mariana-Carmen</creatorcontrib><creatorcontrib>Bleotu, Coralia</creatorcontrib><creatorcontrib>Grecu, Maria Nicoleta</creatorcontrib><creatorcontrib>Iorgulescu, Emilia-Elena</creatorcontrib><creatorcontrib>Lazar, Veronica</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olar, Rodica</au><au>Badea, Mihaela</au><au>Marinescu, Dana</au><au>Chifiriuc, Mariana-Carmen</au><au>Bleotu, Coralia</au><au>Grecu, Maria Nicoleta</au><au>Iorgulescu, Emilia-Elena</au><au>Lazar, Veronica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>45</volume><issue>7</issue><spage>3027</spage><epage>3034</epage><pages>3027-3034</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>The new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesized and characterized by IR, EPR,
1H NMR,
13C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)
2](ClO
4)
2·2DMF (DMF:
N,
N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)
2](ClO
4)
2 adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free
N,
N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of
Pseudomonas aeruginosa and
Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.
A series of new complexes M(DMBG)
2(ClO
4)
2 (M:Mn, Ni, Cu and Zn; DMBG:
N,
N-dimethylbiguanide) have been synthesised and evaluated for their antimicrobial, antibiofilm as well as cytostatic activity.
[Display omitted]</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>20403647</pmid><doi>10.1016/j.ejmech.2010.03.033</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2010-07, Vol.45 (7), p.3027-3034 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | Elsevier |
| subjects | Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - toxicity Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial activity Bacteria - drug effects Bacterial biofilm Biological and medical sciences Complex Crystallography, X-Ray Cytotoxicity Electrochemistry Fungi - drug effects General aspects HeLa Cells Humans Medical sciences Metformin - chemistry Metformin - pharmacology Metformin - toxicity N,N-dimethylbiguanide Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Organometallic Compounds - toxicity Oxidation-Reduction Pharmacology. Drug treatments Spectrum Analysis Stereoisomerism |
| title | N, N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents |
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