The bisphosphonates alendronate and zoledronate are inhibitors of canine and human osteosarcoma cell growth in vitro

Bisphosphonates (BPs) are a class of non‐hydrolysable analogues of pyrophosphate that have high affinity for bone mineral and are inhibitors of bone resorption. The in vitro effects of two nitrogen‐containing BPs, alendronate (ALE) and zoledronate (ZOL), on growth, induction of apoptosis and effects...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary & comparative oncology 2003-12, Vol.1 (4), p.207-215
Main Authors: Poirier, V. J., Huelsmeyer, M. K., Kurzman, I. D., Thamm, D. H., Vail, D. M.
Format: Article
Language:English
Subjects:
apoptosis
bisphosphonates
dog
zoledronic acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bisphosphonates (BPs) are a class of non‐hydrolysable analogues of pyrophosphate that have high affinity for bone mineral and are inhibitors of bone resorption. The in vitro effects of two nitrogen‐containing BPs, alendronate (ALE) and zoledronate (ZOL), on growth, induction of apoptosis and effects on cell‐cycle distribution in two canine and two human osteosarcoma (OSA) cell lines are investigated here. Both significantly (P 
ISSN:1476-5810
1476-5829
DOI:10.1111/j.1476-5810.2003.00026.x