Highly Controlled Silica Coating of PEG-Capped Metal Nanoparticles and Preparation of SERS-Encoded Particles

Thiol-modified poly(ethylene glycol) (mPEG-SH) has been used to replace standard capping agents from the surfaces of gold nanoparticles with different sizes and shapes. Upon PEG stabilization, the nanoparticles can be transferred into ethanol, where silica can be directly grown on the particle surfa...

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Bibliographic Details
Published in:Langmuir 2009-12, Vol.25 (24), p.13894-13899
Main Authors: Fernández-López, Cristina, Mateo-Mateo, Cintia, Álvarez-Puebla, Ramón A, Pérez-Juste, Jorge, Pastoriza-Santos, Isabel, Liz-Marzán, Luis M
Format: Article
Language:English
Subjects:
Coated Materials, Biocompatible - chemical synthesis
Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams
Ethanol
Metal Nanoparticles - chemistry
Polyethylene Glycols - chemistry
Silicon Dioxide - chemistry
Spectrum Analysis, Raman - methods
Sulfhydryl Compounds
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Summary:Thiol-modified poly(ethylene glycol) (mPEG-SH) has been used to replace standard capping agents from the surfaces of gold nanoparticles with different sizes and shapes. Upon PEG stabilization, the nanoparticles can be transferred into ethanol, where silica can be directly grown on the particle surfaces through the standard Stöber process. The obtained silica shells are uniform and homogeneous, and the method allows a high degree of control over shell thickness for any particle size and shape. Additionally, Raman-active molecules can be readily incorporated within the composite nanoparticles during silica growth so that SERS/SERRS-encoded nanoparticles can be fabricated containing a variety of tags, thereby envisaging multiplexing capability.
ISSN:0743-7463
1520-5827
DOI:10.1021/la9016454