Amphotericin versus pentamidine in antimony-unresponsive kala-azar

We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar. Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen defi...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 1992-11, Vol.340 (8830), p.1256-1257
Main Authors: Mishra, M., Biswas, U.K., Jha, D.N., Khan, A.B.
Format: Article
Language:English
Subjects:
Adult
Amphotericin B - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimony
Antimony Sodium Gluconate - therapeutic use
Antiparasitic agents
Biological and medical sciences
Drugs
Female
Fungi
Humans
Leishmaniasis, Visceral - drug therapy
Male
Medical research
Medical sciences
Parasites
Pentamidine - therapeutic use
Pharmacology. Drug treatments
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar. Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen definitive doses of amphotericin 0·5 mg/kg infused in 5% dextrose on alternate days. 48 (80%) patients given pentamidine showed initial cure and 46 (77%) showed definitive cure compared with 60 (100%) and 59 (98%) cases, respectively, on amphotericin (p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(92)92952-C