Guidance molecules in lung cancer

Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer devel...

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Bibliographic Details
Published in:Cell adhesion & migration 2010-01, Vol.4 (1), p.130-145
Main Authors: Nasarre, Patrick, Potiron, Vincent, Drabkin, Harry, Roche, Joëlle
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Signal Transducing - metabolism
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Humans
Landes
Life Sciences
Lung
Lung - embryology
Lung - metabolism
Lung Neoplasms
Lung Neoplasms - metabolism
Lung Neoplasms - therapy
Organogenesis
Proteins
Signal Transduction
Special Focus: Lung Cancers
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Description
Summary:Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed.
ISSN:1933-6918
1933-6926
DOI:10.4161/cam.4.1.10882