Portal Osmopressor Mechanism Linked to Transient Receptor Potential Vanilloid 4 and Blood Pressure Control

Human subjects with impaired baroreflex function cannot buffer rises or falls in blood pressure (BP), thus allowing BP effects of endogenous or environmental stimuli that previously escaped detection to emerge dramatically. Studies in these patients led us to discover that water ingestion induced a...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-06, Vol.55 (6), p.1438-1443
Main Authors: McHugh, Julia, Keller, Nancy R, Appalsamy, Martin, Thomas, Steven A, Raj, Satish R, Diedrich, André, Biaggioni, Italo, Jordan, Jens, Robertson, David
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Baroreflex - drug effects
Baroreflex - physiology
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure Determination
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Disease Models, Animal
Humans
Hypertension - metabolism
Hypertension - physiopathology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Osmotic Pressure
Prazosin - pharmacology
Probability
Random Allocation
Statistics, Nonparametric
Sympathetic Nervous System - physiology
TRPV Cation Channels - physiology
Vagotomy - methods
Vascular Resistance - drug effects
Vascular Resistance - physiology
Water - administration & dosage
Water-Electrolyte Balance - physiology
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Summary:Human subjects with impaired baroreflex function cannot buffer rises or falls in blood pressure (BP), thus allowing BP effects of endogenous or environmental stimuli that previously escaped detection to emerge dramatically. Studies in these patients led us to discover that water ingestion induced a robust increase in BP and vascular resistance. Here, using a mouse model of baroreflex impairment, we show that the increase in blood pressure after water ingestion is mediated through sympathetic nervous system activation and that the osmosensitive transient receptor potential vanilloid 4 channel (Trpv4) is an essential component of the response. Although portal osmolality decreases after water ingestion in both wild-type and Trpv4 mice, only the wild-type animals show a pressor response. The same volume of physiological saline does not elicit an increase in BP, suggesting osmolality as the stimulus. The osmopressor response to water, and Trpv4 thus represent new factors now implicated in the physiology of BP regulation.
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.110.151860