Dynamics of nonmembranous cell components: Role of active transport along microtubules

Here we discuss some common mechanisms of microtubule-dependent active transport of nonmembranous components in animal cells. We summarize data about mRNA, cytoskeletal elements, structural proteins, and signaling complexes transport. We also characterize the series of molecular interactions that co...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2010, Vol.75 (1), p.7-18
Main Authors: Lomakin, A. Yu, Nadezhdina, E. S
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological Transport, Active - physiology
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cell Line
Cells
Cytoskeletal Proteins - metabolism
Cytoskeleton
Dynein
Kinesin
Life Sciences
Messenger RNA
Microbiology
Microtubules - metabolism
Mitochondrial DNA
Molecular Motor Proteins - metabolism
Proteins
Review
Ribonucleic acid
RNA
RNA, Messenger - metabolism
Signal Transduction
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Summary:Here we discuss some common mechanisms of microtubule-dependent active transport of nonmembranous components in animal cells. We summarize data about mRNA, cytoskeletal elements, structural proteins, and signaling complexes transport. We also characterize the series of molecular interactions that connect nonmembranous cargoes and microtubules and describe the regulatory pathways for these interactions.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297910010025