Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome

To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction. Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measu...

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Bibliographic Details
Published in:Clinical biochemistry 2010-07, Vol.43 (10), p.851-857
Main Authors: Iversen, Kasper K., Dalsgaard, Morten, Teisner, Ane S., Schoos, Mikkel, Teisner, Borge, Nielsen, Henrik, Grande, Peer, Clemmensen, Peter
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - blood
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Chest Pain - blood
Coronary heart disease
Female
Heart
Humans
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Pregnancy-associated plasma protein A
Pregnancy-Associated Plasma Protein-A - analysis
Prognosis
Risk Factors
Treatment Outcome
Young Adult
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Summary:To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction. Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction. Median age of patients included (415) was 67 years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7, p < 0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4, p = 0.01). In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2010.03.018