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Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome
To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction. Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measu...
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| Published in: | Clinical biochemistry 2010-07, Vol.43 (10), p.851-857 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c406t-d2aebe34a7638a60c13f4759ec7c0dcb39d57c2d9f4e90c356b61bd46e78a0cf3 |
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| cites | cdi_FETCH-LOGICAL-c406t-d2aebe34a7638a60c13f4759ec7c0dcb39d57c2d9f4e90c356b61bd46e78a0cf3 |
| container_end_page | 857 |
| container_issue | 10 |
| container_start_page | 851 |
| container_title | Clinical biochemistry |
| container_volume | 43 |
| creator | Iversen, Kasper K. Dalsgaard, Morten Teisner, Ane S. Schoos, Mikkel Teisner, Borge Nielsen, Henrik Grande, Peer Clemmensen, Peter |
| description | To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction.
Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction.
Median age of patients included (415) was 67
years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7,
p
<
0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4,
p
=
0.01).
In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction. |
| doi_str_mv | 10.1016/j.clinbiochem.2010.03.018 |
| format | article |
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Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction.
Median age of patients included (415) was 67
years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7,
p
<
0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4,
p
=
0.01).
In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2010.03.018</identifier><identifier>PMID: 20388505</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Acute coronary syndrome ; Acute Coronary Syndrome - blood ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Chest Pain - blood ; Coronary heart disease ; Female ; Heart ; Humans ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Pregnancy-associated plasma protein A ; Pregnancy-Associated Plasma Protein-A - analysis ; Prognosis ; Risk Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Clinical biochemistry, 2010-07, Vol.43 (10), p.851-857</ispartof><rights>2010 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-d2aebe34a7638a60c13f4759ec7c0dcb39d57c2d9f4e90c356b61bd46e78a0cf3</citedby><cites>FETCH-LOGICAL-c406t-d2aebe34a7638a60c13f4759ec7c0dcb39d57c2d9f4e90c356b61bd46e78a0cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22955884$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20388505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iversen, Kasper K.</creatorcontrib><creatorcontrib>Dalsgaard, Morten</creatorcontrib><creatorcontrib>Teisner, Ane S.</creatorcontrib><creatorcontrib>Schoos, Mikkel</creatorcontrib><creatorcontrib>Teisner, Borge</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Grande, Peer</creatorcontrib><creatorcontrib>Clemmensen, Peter</creatorcontrib><title>Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction.
Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction.
Median age of patients included (415) was 67
years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7,
p
<
0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4,
p
=
0.01).
In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction.</description><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>Chest Pain - blood</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Pregnancy-associated plasma protein A</subject><subject>Pregnancy-Associated Plasma Protein-A - analysis</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkM3P1CAQh4nR-K6v_gsGD8aLXaG0tBzNxq_kTfSgZzIdpsraQoXWZP972ez6cZTLBPL8ZpiHsWdS7KWQ-tVxj5MPg4_4jeZ9Lcq7UHsh-3tsJ_tOVbVR6j7bCSFMZWQtbtijnI_lWje9fshuaqH6vhXtjs2fEn0NEPBUQc4RPazk-DJBnoEvKa7kQwUvOfAZ0ndKfIyJx23FOBP3gS-wegpr5nnLC-E5fCYAt5U4xhQDpBPPp-BSSTxmD0aYMj251lv25e2bz4f31d3Hdx8Or-8qbIReK1cDDaQa6LTqQQuUamy61hB2KBwOyri2w9qZsSEjULV60HJwjaauB4GjumUvLn3LBj82yqudfUaaJggUt2w7VY5WjSykuZCYYs6JRrskX1Y9WSnsWbY92n9k27NsK5Qtskv26XXKNszk_iR_2y3A8ysAGWEaU_Hs81-uNm3b903hDheOipOfnpLNWKwiOZ-KU-ui_4_v_AI8B6XI</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Iversen, Kasper K.</creator><creator>Dalsgaard, Morten</creator><creator>Teisner, Ane S.</creator><creator>Schoos, Mikkel</creator><creator>Teisner, Borge</creator><creator>Nielsen, Henrik</creator><creator>Grande, Peer</creator><creator>Clemmensen, Peter</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome</title><author>Iversen, Kasper K. ; Dalsgaard, Morten ; Teisner, Ane S. ; Schoos, Mikkel ; Teisner, Borge ; Nielsen, Henrik ; Grande, Peer ; Clemmensen, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-d2aebe34a7638a60c13f4759ec7c0dcb39d57c2d9f4e90c356b61bd46e78a0cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>Chest Pain - blood</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Pregnancy-associated plasma protein A</topic><topic>Pregnancy-Associated Plasma Protein-A - analysis</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iversen, Kasper K.</creatorcontrib><creatorcontrib>Dalsgaard, Morten</creatorcontrib><creatorcontrib>Teisner, Ane S.</creatorcontrib><creatorcontrib>Schoos, Mikkel</creatorcontrib><creatorcontrib>Teisner, Borge</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Grande, Peer</creatorcontrib><creatorcontrib>Clemmensen, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iversen, Kasper K.</au><au>Dalsgaard, Morten</au><au>Teisner, Ane S.</au><au>Schoos, Mikkel</au><au>Teisner, Borge</au><au>Nielsen, Henrik</au><au>Grande, Peer</au><au>Clemmensen, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>43</volume><issue>10</issue><spage>851</spage><epage>857</epage><pages>851-857</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction.
Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A. Main outcome measures were mortality and non-fatal myocardial infarction.
Median age of patients included (415) was 67
years and 43% were women. The risk of death or non-fatal myocardial infarction after 3 months was 15% in the highest quartile of circulating PAPP-A compared with 3% in the lowest quartile (relative risk 3.7,
p
<
0.01). Corresponding numbers after 1 year were 24% and 10% (relative risk 2.4,
p
=
0.01).
In patients admitted with chest pain and both normal ECG and normal biomarkers PAPP-A seems to be valuable for predicting patients at high risk of death or non-fatal myocardial infarction.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20388505</pmid><doi>10.1016/j.clinbiochem.2010.03.018</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical biochemistry, 2010-07, Vol.43 (10), p.851-857 |
| issn | 0009-9120 1873-2933 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Acute coronary syndrome Acute Coronary Syndrome - blood Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Chest Pain - blood Coronary heart disease Female Heart Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Pregnancy-associated plasma protein A Pregnancy-Associated Plasma Protein-A - analysis Prognosis Risk Factors Treatment Outcome Young Adult |
| title | Pregnancy-associated plasma protein-a, a marker for outcome in patients suspected for acute coronary syndrome |
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