Reactive nonsexually related acute genital ulcers: Review of cases evaluated at Mayo Clinic

Background Reactive nonsexually related acute genital ulcers (RNSRAGU) occur in pubertal girls after an acute systemic infection. Objective We sought to characterize RNSRAGU by reviewing the medical records of patients with this disorder. Methods We searched our medical index database from 1997 to 2...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2010-07, Vol.63 (1), p.44-51
Main Authors: Lehman, Julia S., MD, Bruce, Alison J., MB, ChB, Wetter, David A., MD, Ferguson, Sara B., MD, Rogers, Roy S., MD
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Analgesics - administration & dosage
Biological and medical sciences
Child
Condylomata Acuminata - diagnosis
Condylomata Acuminata - drug therapy
Condylomata Acuminata - etiology
Dermatology
Female
Gastroenteritis - complications
genital ulcers
Humans
Infection - complications
Influenza, Human - complications
Lipschütz ulcer
Medical sciences
Pharyngitis - complications
Prognosis
Respiratory Tract Infections - complications
Retrospective Studies
Streptococcal Infections - complications
Surveys and Questionnaires
ulcus vulvae acutum
Virus Diseases - complications
Vulvar Diseases - diagnosis
Vulvar Diseases - drug therapy
Vulvar Diseases - etiology
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Summary:Background Reactive nonsexually related acute genital ulcers (RNSRAGU) occur in pubertal girls after an acute systemic infection. Objective We sought to characterize RNSRAGU by reviewing the medical records of patients with this disorder. Methods We searched our medical index database from 1997 to 2007 for RNSRAGU cases. Questionnaires were mailed to identified patients. Results The study included 10 patients; 5 responded to the questionnaire. The mean age at onset was 11.5 years. Vulvar ulcers were preceded by viral gastroenteritis (n = 3), viral upper respiratory tract infection (n = 3), streptococcal pharyngitis (n = 1), influenza (n = 1), and other nonspecific febrile illnesses (n = 2). Seven patients had oral involvement also; 6 had at least one recurrence; and 3 were hospitalized for pain control. Analgesics and topical corticosteroids were the most common treatments. Ulcerations resolved within several weeks in all patients. Limitations Retrospective study design, small study size, and 50% questionnaire response rate are limitations. Conclusions Although rare, RNSRAGU should be considered when genital ulceration follows an acute systemic illness.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2009.08.038