Hypermetabolism in Patients With Dementia With Lewy Bodies

PURPOSE:Detection of hyperperfusion by I-123 N-isopropyl-p-iodoamphetamine single photon emission computed tomography can be helpful to diagnose dementia with Lewy bodies (DLB). This study characterized hypermetabolism in DLB. MATERIALS AND METHODS:A total of 22 probable cases of DLB were examined b...

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Bibliographic Details
Published in:Clinical nuclear medicine 2010-07, Vol.35 (7), p.490-493
Main Authors: Miyazawa, Nobuhiko, Shinohara, Toyoaki, Nagasaka, Takamura, Hayashi, Masataka
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cerebellum - metabolism
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Lewy Body Disease - diagnostic imaging
Lewy Body Disease - metabolism
Male
Middle Aged
Positron-Emission Tomography
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Summary:PURPOSE:Detection of hyperperfusion by I-123 N-isopropyl-p-iodoamphetamine single photon emission computed tomography can be helpful to diagnose dementia with Lewy bodies (DLB). This study characterized hypermetabolism in DLB. MATERIALS AND METHODS:A total of 22 probable cases of DLB were examined by F-18 2-fluoro-2-deoxy-D-glucose positron emission tomography. RESULTS:Hypermetabolism was found in the peri-motor area, basal ganglia, and cerebellum. Eleven patients had hypermetabolism in all 3 areas, 6 in 2 areas, 4 in 1 area, and 1 in no area. Hypermetabolism was most frequent in the cerebellum. Comparison of the 11 patients with hypermetabolism in all 3 areas to the other 11 cases found no significant differences in age (P = 0.2555), sex (P = 0.1889), Mini-Mental State Examination score (P = 0.0897), and Parkinsonism. However, visual hallucinations were significantly more frequent in the patients with hypermetabolism in all 3 areas (P = 0.0018). CONCLUSIONS:Hypermetabolism is common in patients with DLB and may be related to visual hallucinations.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0b013e3181e05dbc