Influence of gel and powdered formulations of coenzyme Q10 on metabolic parameters in rats

The healthful benefits of two commercially available formulations of coenzyme Q10 (Co Q10), one in gel and the other in a powdered form, on a variety of metabolic parameters in Sprague-Dawley rats (SD) were compared to control. The principal metabolic parameters examined were systolic blood pressure...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2010-07, Vol.340 (1-2), p.169-173
Main Authors: Preuss, Harry G, Echard, Bobby, Bagchi, Debasis, Clouatre, Dallas, Perricone, Nicholas V
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biochemistry
Biomedical and Life Sciences
Blood pressure
Blood Pressure - drug effects
Body Weight
Cardiology
Chemical compounds
Chemistry, Pharmaceutical
Coenzyme Q10, antioxidant effects
Coenzyme Q10, DNA fragmentation
Coenzyme Q10, gel and powdered formulations
Coenzyme Q10, systolic blood pressure
Deoxyribonucleic acid
Dietary Supplements
DNA
DNA Fragmentation
Free Radicals - metabolism
Gels
Kidney - drug effects
Kidney - metabolism
Life Sciences
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Medical Biochemistry
Metabolism
Oncology
Powders
Rats
Rats, Sprague-Dawley
Rodents
Time Factors
Ubiquinone - chemistry
Ubiquinone - pharmacology
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Summary:The healthful benefits of two commercially available formulations of coenzyme Q10 (Co Q10), one in gel and the other in a powdered form, on a variety of metabolic parameters in Sprague-Dawley rats (SD) were compared to control. The principal metabolic parameters examined were systolic blood pressure (SBP), DNA fragmentation, and free radical formation in hepatic and renal tissues. Compared to control, the powdered formulation significantly decreased SBP in the normotensive SD, whereas both commercial formulations lowered hepatic and renal DNA fragmentation and free radical formation. The gel-formulation lowered hepatic DNA fragmentation more than the powdered-formulation. In conclusion, both gel- and powdered-formulations of Co Q10 significantly influenced the metabolic parameters assessed in a favorable fashion, with the powdered-formulation more effective on SBP and the gel-formulation more effective on overcoming hepatic DNA fragmentation. From the data, we conclude that the choice of the formulation containing Co Q10 to be used should be based on the desired healthful benefits.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-010-0414-9