Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

Split personality: A series of oligoamide‐based helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid‐free conditions, but inhibited it under...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-01, Vol.49 (4), p.736-739
Main Authors: Saraogi, Ishu, Hebda, James A, Becerril, Jorge, Estroff, Lara A, Miranker, Andrew D, Hamilton, Andrew D
Format: Article
Language:English
Subjects:
Amides - chemistry
Amyloid - agonists
Amyloid - antagonists & inhibitors
Amyloid - metabolism
amyloid β-peptides
Crystallography, X-Ray
diabetes
helical structures
Hydrogen Bonding
Islet Amyloid Polypeptide
Kinetics
Molecular Conformation
Phosphatidylcholines - chemistry
Phosphatidylglycerols - chemistry
Protein Binding
proteomimetics
α-helix mimetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Split personality: A series of oligoamide‐based helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid‐free conditions, but inhibited it under lipid‐catalyzed conditions. hIAPP=human IAPP.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200901694