The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles

Caveolin is a protein present in membrane specializations termed caveolae where it may play a structural role. Previous studies on the cDNA sequence of chicken caveolin demonstrated that it is an integral membrane protein without significant homology to any known protein. The cDNA sequence of human...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1992-12, Vol.314 (1), p.45-48
Main Author: Glenney, John R.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Biological and medical sciences
Biological Transport
Carrier Proteins - genetics
caveolin
Caveolin 1
Caveolins
cDNA
DNA sequence
Fundamental and applied biological sciences. Psychology
genes
Genes. Genome
homology
Humans
lung
man
Membrane Proteins - genetics
Membrane transport
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
nucleotide sequence
Oncogene
Poly A - analysis
predictions
RNA, Messenger - analysis
Sequence Homology, Amino Acid
Tissue Distribution
Tyrosine kinase
VIP21 protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Caveolin is a protein present in membrane specializations termed caveolae where it may play a structural role. Previous studies on the cDNA sequence of chicken caveolin demonstrated that it is an integral membrane protein without significant homology to any known protein. The cDNA sequence of human lung caveolin is presented here. A striking sequence homology is observed with the chicken protein, as well as a very recently reported protein termed VIP21 [(1992) J. Cell Biol. 118, 1003–1014], a putative vesicle transport protein isolated from MDCK cells. Genomic Southern blots suggest that caveolin is present in a single copy, and Northern blots confirm that the caveolin mRNA is elevated in muscle.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)81458-X