Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus

Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is the most recently discovered human oncogenic herpesvirus. The virus is associated with KS lesions and other human malignancies, including pleural effusion lymphomas and multicentric castleman’s disease. The sequence of the viral genome demonstrate...

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Bibliographic Details
Published in:FEMS Microbiology Letters 2003-05, Vol.222 (2), p.155-163
Main Authors: Verma, Subhash C., Robertson, Erle S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Transformation, Neoplastic
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Viral
Herpesvirus 8, Human - genetics
Humans
Immunosuppression and cell cycle regulation
Kaposi sarcoma-associated herpesvirus
Latency-associated nuclear antigen
Microbiology
Molecular Biology
Mycology
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Sarcoma, Kaposi - genetics
Sarcoma, Kaposi - pathology
Sarcoma, Kaposi - virology
Virology
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Summary:Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is the most recently discovered human oncogenic herpesvirus. The virus is associated with KS lesions and other human malignancies, including pleural effusion lymphomas and multicentric castleman’s disease. The sequence of the viral genome demonstrated that it belongs to the gammaherpesvirus family similar to the Epstein–Barr virus, the only other known human herpesvirus associated with human cancers. Molecular studies have identified a number of viral genes involved in regulation of cell proliferation, gene regulation, chromatin remodeling and apoptosis. KSHV transforms human endothelial cells in vitro with low efficiency and expresses a repertoire of latent genes involved in the establishment of latency. One of these latent proteins, the latency-associated nuclear antigen (LANA) is required for episomal maintenance and tethers the viral genome to the host chromatin. LANA has now been shown to be a multifunctional protein involved in numerous cellular functions including binding to the retinoblastoma protein and p53, regulating cell proliferation and apoptosis.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(03)00261-1