Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis

CCAAT/enhancer binding proteins (C/EBPs) are a group of transcription factors which have been implicated in cellular proliferation, terminal differentiation, and apoptosis in a variety of tissues including mammary gland. Owing to its role in various cellular functions, inactivation of C/EBP proteins...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2010-04, Vol.337 (1-2), p.111-118
Main Authors: Pal, Pooja, Lochab, Savita, Kanaujiya, Jitendra, Sanyal, Sabyasachi, Trivedi, Arun Kumar
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Apoptosis Regulatory Proteins - genetics
Binding proteins
Biochemistry
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cardiology
CCAAT-Enhancer-Binding Proteins - genetics
CCAAT-Enhancer-Binding Proteins - physiology
Cell Proliferation
DNA Fragmentation
Enzymes
Female
Gene Expression Regulation, Neoplastic
Humans
Inactivation
Life Sciences
Medical Biochemistry
Oncology
Poly(ADP-ribose) Polymerases - genetics
Poly(ADP-ribose) Polymerases - metabolism
Protein binding
Proteins
Time Factors
Transfection
Tumor Cells, Cultured
Tumors
Up-Regulation - genetics
Up-Regulation - physiology
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Summary:CCAAT/enhancer binding proteins (C/EBPs) are a group of transcription factors which have been implicated in cellular proliferation, terminal differentiation, and apoptosis in a variety of tissues including mammary gland. Owing to its role in various cellular functions, inactivation of C/EBP proteins is central to the pathogenesis of many disorders. Recent reports suggest that expression as well as function of C/EBP proteins is deregulated in breast tumors. Although, role of C/EBPs in growth arrest in mammary tissues has been studied in much detail; their role in apoptosis is relatively less explored. In the present study, we have assessed if breast tumors evade apoptosis and grow faster by down regulating and inhibiting the C/EBP proteins, C/EBPα in particular. Our data shows that ectopic expression of human C/EBPs in breast tumor cells inhibits proliferation and induces apoptosis which is likely to be associated with caspase dependent pathway.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-009-0290-3