Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography

Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to eva...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2009-06, Vol.35 (6), p.678-682
Main Authors: Tokudome, Yoshihiro, Ohshima, Hiroyuki, Otsuka, Makoto
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry, Pharmaceutical - methods
General pharmacology
Medical sciences
Noninvasive observation
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
press-coated tablets
Quality Control
quality control of production
Tablets
Technology, Pharmaceutical - methods
Tomography, X-Ray Computed - methods
X-ray computed tomography
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Summary:Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to evaluate the internal structure of commercial press-coated tablets by using X-ray CT. Method: Thirty-two CT image slices of four kinds of commercial press-coated tablets (tablets A, B, C, and D) were measured 300 m interval between edges of the tablet by using an X-ray CT. The thinnest layer thickness of the tablets and distance between centers of gravity (DCG) of tables were calculated. Results: The order of the TLT of the tablets was tablet B > tablet C > tablet D > tablet A. The result indicated that the order of DCG was tablet A > tablet D > tablet C > tablet B. Noninvasive observation of the internal structure of commercial, press-coated tablets by X-ray CT has been demonstrated to be useful in quality control of production. Conclusion: The internal structure of press-coated tablets could be observed without pretreatment, without destruction, and very rapidly by X-ray CT.
ISSN:0363-9045
1520-5762
DOI:10.1080/03639040802587807