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Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography
Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to eva...
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| Published in: | Drug development and industrial pharmacy 2009-06, Vol.35 (6), p.678-682 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c431t-4122ada6ade18a49f23b8c04850577fc4606a59313372b4f5d1ff1f624f221783 |
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| cites | cdi_FETCH-LOGICAL-c431t-4122ada6ade18a49f23b8c04850577fc4606a59313372b4f5d1ff1f624f221783 |
| container_end_page | 682 |
| container_issue | 6 |
| container_start_page | 678 |
| container_title | Drug development and industrial pharmacy |
| container_volume | 35 |
| creator | Tokudome, Yoshihiro Ohshima, Hiroyuki Otsuka, Makoto |
| description | Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to evaluate the internal structure of commercial press-coated tablets by using X-ray CT. Method: Thirty-two CT image slices of four kinds of commercial press-coated tablets (tablets A, B, C, and D) were measured 300 m interval between edges of the tablet by using an X-ray CT. The thinnest layer thickness of the tablets and distance between centers of gravity (DCG) of tables were calculated. Results: The order of the TLT of the tablets was tablet B > tablet C > tablet D > tablet A. The result indicated that the order of DCG was tablet A > tablet D > tablet C > tablet B. Noninvasive observation of the internal structure of commercial, press-coated tablets by X-ray CT has been demonstrated to be useful in quality control of production. Conclusion: The internal structure of press-coated tablets could be observed without pretreatment, without destruction, and very rapidly by X-ray CT. |
| doi_str_mv | 10.1080/03639040802587807 |
| format | article |
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Aim: A novel, fast, noninvasive tablet observation method was developed to evaluate the internal structure of commercial press-coated tablets by using X-ray CT. Method: Thirty-two CT image slices of four kinds of commercial press-coated tablets (tablets A, B, C, and D) were measured 300 m interval between edges of the tablet by using an X-ray CT. The thinnest layer thickness of the tablets and distance between centers of gravity (DCG) of tables were calculated. Results: The order of the TLT of the tablets was tablet B > tablet C > tablet D > tablet A. The result indicated that the order of DCG was tablet A > tablet D > tablet C > tablet B. Noninvasive observation of the internal structure of commercial, press-coated tablets by X-ray CT has been demonstrated to be useful in quality control of production. Conclusion: The internal structure of press-coated tablets could be observed without pretreatment, without destruction, and very rapidly by X-ray CT.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639040802587807</identifier><identifier>PMID: 19274513</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Chemistry, Pharmaceutical - methods ; General pharmacology ; Medical sciences ; Noninvasive observation ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; press-coated tablets ; Quality Control ; quality control of production ; Tablets ; Technology, Pharmaceutical - methods ; Tomography, X-Ray Computed - methods ; X-ray computed tomography</subject><ispartof>Drug development and industrial pharmacy, 2009-06, Vol.35 (6), p.678-682</ispartof><rights>Informa UK, Ltd. 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-4122ada6ade18a49f23b8c04850577fc4606a59313372b4f5d1ff1f624f221783</citedby><cites>FETCH-LOGICAL-c431t-4122ada6ade18a49f23b8c04850577fc4606a59313372b4f5d1ff1f624f221783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21543408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19274513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokudome, Yoshihiro</creatorcontrib><creatorcontrib>Ohshima, Hiroyuki</creatorcontrib><creatorcontrib>Otsuka, Makoto</creatorcontrib><title>Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to evaluate the internal structure of commercial press-coated tablets by using X-ray CT. Method: Thirty-two CT image slices of four kinds of commercial press-coated tablets (tablets A, B, C, and D) were measured 300 m interval between edges of the tablet by using an X-ray CT. The thinnest layer thickness of the tablets and distance between centers of gravity (DCG) of tables were calculated. Results: The order of the TLT of the tablets was tablet B > tablet C > tablet D > tablet A. The result indicated that the order of DCG was tablet A > tablet D > tablet C > tablet B. Noninvasive observation of the internal structure of commercial, press-coated tablets by X-ray CT has been demonstrated to be useful in quality control of production. Conclusion: The internal structure of press-coated tablets could be observed without pretreatment, without destruction, and very rapidly by X-ray CT.</description><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Noninvasive observation</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>press-coated tablets</subject><subject>Quality Control</subject><subject>quality control of production</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>X-ray computed tomography</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFTEYhYMo9rb6A9xINuJqNJ_zgW6kaBVKu1FwN7yTSXpTZiZj3syVAX-8ud6rpQhd5SXnOSfJCSEvOHvDWc3eMlnKhqk8Cl1XNasekQ3XghW6KsVjstnrRQb0CTlFvGWMi0brp-SEN6JSmssN-XUVpsJPO0C_sxSmnkaYfZ8nGFb0SF2INHRo4w6SDxMNjvop2Zh1iikuJi3R7nfnaBELEyDZniboBpvogn66od-LCCs1YZyXP1oYw00-Zbs-I08cDGifH9cz8u3Tx6_nn4vL64sv5x8uC6MkT4XiQkAPJfSW16AaJ2RXG6ZqzXRVOaNKVoJuJJeyEp1yuufOcVcK5YTgVS3PyOtD7hzDj8ViakePxg4DTDYs2FZSSp29ZSb5gTQxIEbr2jn6EeLactbuO2__6zx7Xh7Tl260_Z3jWHIGXh0BQAODizAZj_84wbWSOTBz7w-cn3LrI_wMcejbBOsQ4l-TfOge7-7ZtxaGtDUQbXsblv2H4QOv-A2HzK_d</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Tokudome, Yoshihiro</creator><creator>Ohshima, Hiroyuki</creator><creator>Otsuka, Makoto</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography</title><author>Tokudome, Yoshihiro ; Ohshima, Hiroyuki ; Otsuka, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-4122ada6ade18a49f23b8c04850577fc4606a59313372b4f5d1ff1f624f221783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Noninvasive observation</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>press-coated tablets</topic><topic>Quality Control</topic><topic>quality control of production</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>X-ray computed tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokudome, Yoshihiro</creatorcontrib><creatorcontrib>Ohshima, Hiroyuki</creatorcontrib><creatorcontrib>Otsuka, Makoto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokudome, Yoshihiro</au><au>Ohshima, Hiroyuki</au><au>Otsuka, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>35</volume><issue>6</issue><spage>678</spage><epage>682</epage><pages>678-682</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Background: Since the internal structure of a tablet can be measured without destruction of the sample by X-ray computed tomography (CT), it could be applied to quality control of tablets during the manufacturing process. Aim: A novel, fast, noninvasive tablet observation method was developed to evaluate the internal structure of commercial press-coated tablets by using X-ray CT. Method: Thirty-two CT image slices of four kinds of commercial press-coated tablets (tablets A, B, C, and D) were measured 300 m interval between edges of the tablet by using an X-ray CT. The thinnest layer thickness of the tablets and distance between centers of gravity (DCG) of tables were calculated. Results: The order of the TLT of the tablets was tablet B > tablet C > tablet D > tablet A. The result indicated that the order of DCG was tablet A > tablet D > tablet C > tablet B. Noninvasive observation of the internal structure of commercial, press-coated tablets by X-ray CT has been demonstrated to be useful in quality control of production. Conclusion: The internal structure of press-coated tablets could be observed without pretreatment, without destruction, and very rapidly by X-ray CT.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>19274513</pmid><doi>10.1080/03639040802587807</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9045 |
| ispartof | Drug development and industrial pharmacy, 2009-06, Vol.35 (6), p.678-682 |
| issn | 0363-9045 1520-5762 |
| language | eng |
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| source | EBSCOhost Business Source Ultimate; Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Biological and medical sciences Chemistry, Pharmaceutical - methods General pharmacology Medical sciences Noninvasive observation Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments press-coated tablets Quality Control quality control of production Tablets Technology, Pharmaceutical - methods Tomography, X-Ray Computed - methods X-ray computed tomography |
| title | Non-invasive and rapid analysis for observation of internal structure of press-coated tablet using X-ray computed tomography |
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