Clinical applications of N-terminal pro B-type natriuretic peptide in heart failure and other cardiovascular diseases

N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) has emerged as an important adjunct in the management of heart failure (HF) and other cardiovascular diseases. NT-proBNP is a 76-amino acid peptide created during cleavage of the precursor molecule, Pro B-type natriuretic peptide (Pro...

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Bibliographic Details
Published in:Heart failure reviews 2010-07, Vol.15 (4), p.293-304
Main Authors: Pu, Da-Rong, Chiong, Jun R., Zhou, Qi-chang
Format: Article
Language:English
Subjects:
Biomarkers
Cardiology
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - pathology
Coronary Artery Disease - pathology
Diastole
Dyspnea
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Failure - pathology
Humans
Kidney Failure, Chronic - pathology
Medicine
Medicine & Public Health
Natriuretic Peptide, Brain
Peptide Fragments
Peripheral Vascular Diseases - pathology
Prognosis
Ventricular Function, Left
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Summary:N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) has emerged as an important adjunct in the management of heart failure (HF) and other cardiovascular diseases. NT-proBNP is a 76-amino acid peptide created during cleavage of the precursor molecule, Pro B-type natriuretic peptide (ProBNP). NT-proBNP is of significant diagnostic value in patients presenting with possible HF and is an important prognostic factor in this condition and other cardiovascular diseases. Ongoing research supports the potential value of this biomarker in non-cardiovascular disease. This review will describe clinical applications of NT-proBNP in HF and a broad range of other conditions.
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-009-9142-1