Oral cephalosporins: current perspectives

Oral cephalosporins had been, for years, a small group of compounds belonging to the first or second-generation cephalosporins, with a limited antimicrobial spectrum. New oral first-generation cephalosporins include cefprozil and loracarbef, similar to cefadroxil and cefaclor, respectively, with act...

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Bibliographic Details
Published in:International journal of antimicrobial agents 1995-07, Vol.5 (4), p.231-243
Main Authors: GARCIA-RODRIGUEZ, J. A, MUNOZ BELLIDO, J. L, GARCIA SANCHEZ, J. E
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cephalosporins
Medical sciences
Oral cephalosporins
Pharmacology. Drug treatments
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Summary:Oral cephalosporins had been, for years, a small group of compounds belonging to the first or second-generation cephalosporins, with a limited antimicrobial spectrum. New oral first-generation cephalosporins include cefprozil and loracarbef, similar to cefadroxil and cefaclor, respectively, with activity similar to cefaclor but with pharmacokinetic improvements. Second-generation oral cephalosporins are esters of already available cephalosporins, and third-generation oral cephalosporins include a number of drugs whose activity is similar to available parenteral drugs, showing pharmacokinetic advantages and, some of them, better resistance to hydrolysis mediated by extended wide-spectrum β-lactamases. They may be a good alternative against mild to moderate ENT infections, UTIs, STDs, lower respiratory tract and skin and soft tissue infections, mainly in the outpatient setting.
ISSN:0924-8579
1872-7913
DOI:10.1016/0924-8579(95)00015-Z